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茶叶科学 ›› 2016, Vol. 36 ›› Issue (3): 250-260.doi: 10.13305/j.cnki.jts.2016.03.004

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茯茶水提物对Ⅱ型糖尿病小鼠糖代谢紊乱的干预作用

黄颂1,2, 刘仲华1,2,3, 黄建安1,3, 阳衡1,2, 李勤1,2,3,*   

  1. 1. 湖南农业大学 教育部茶学重点实验室,湖南 长沙 410128;
    2. 国家植物功能成分利用工程技术研究中心,湖南 长沙 410128;
    3. 湖南省植物功能成分利用协同创新中心,湖南 长沙 410128
  • 收稿日期:2015-11-17 出版日期:2016-06-15 发布日期:2019-08-23
  • 通讯作者: *,liqinvip@126.com
  • 作者简介:黄颂,男,硕士研究生,主要从事茶叶功能成分化学研究。
  • 基金资助:
    国家自然科学基金(31471706)、湖南省自然科学基金(13JJ4067)、湖南省科技项目(15C0670)、湖南农业大学引进人才科学基金(13YJ13)

Intervention Effects of Fuzhuan Brick Tea Water Extract on Glucose Metabolism Disorder in a Mouse Model of Type Ⅱ Diabetes Mellitus

HUANG Song1,2, LIU Zhonghua1,2,3, HUANG Jian′an1,3, YANG Heng1,2, LI Qin1,2,3,*   

  1. 1. Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China;
    2. National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Changsha 410128, China;
    3. Hunan Co-Innovation Center for Utilization of Botanical Functional Ingredients, Changsha 410128, China
  • Received:2015-11-17 Online:2016-06-15 Published:2019-08-23

摘要: 采用高脂高糖饲料联合链脲佐菌素诱导Ⅱ型糖尿病小鼠模型,研究茯砖茶水提物对Ⅱ型糖尿病小鼠的降糖功效。结果表明,茯茶水提取物干预能显著改善糖尿病小鼠多食、多饮、多尿、消瘦症状,降低空腹血糖浓度,提高机体对糖负荷的耐受性,提升胰岛素和胰岛素敏感水平,降低胰岛素抵抗水平。同时,qRT-PCR分析发现,茯茶水提物通过增强PPAR-α、GLUT2和GLUT4基因表达,促进了葡萄糖转运和肝脏内脂质代谢,从而改善糖尿病小鼠体内糖代谢紊乱。综上所述,茯茶能显著改善Ⅱ型糖尿病小鼠糖代谢紊乱症状,其中中、高剂量茯茶效果最为显著。

关键词: 茯茶水提物, Ⅱ型糖尿病, 降糖, 糖代谢

Abstract: In this study, streptozotocin (STZ) combined with a high-fat and high-sugar diet was used to generate a mouse model of type 2 diabetes mellitus. The aim of this study was to investigate the hypoglycemic effects of Fuzhuan brick tea water extract (FTEs) on T2DM-Mice. Results showed that FTEs could obviously alleviate weight loss, polyuria, polydipsia, and polyphagia, reduce fasting plasma glucose, increase sugar tolerance, enhance insulin concentrations and insulin sensitivity and decrease insulin resistance in the diabetic mice. Moreover, RT-qPCR analysis showed that FTEs promoted glucose transport and liver lipid metabolism, and improved the glucose metabolism in the diabetic mice by increasing the expression of PPAR-α, GLUT2, and GLUT4. Therefore, it can be concluded that FTEs could significantly improve glucose metabolism disorder symptom of T2DM-Mice by a dose-dependent manner.

Key words: Fuzhuan brick tea water extract, type 2 diabetes mellitus, hypoglycemic, glucose metabolism

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