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茶叶科学 ›› 2009, Vol. 29 ›› Issue (1): 41-46.doi: 10.13305/j.cnki.jts.2009.1.007

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普洱茶功能成分单体降糖降脂作用研究

张冬英1,2, 邵宛芳1, 刘仲华2,*, 刘亚林3, 黄业伟1   

  1. 1. 云南农业大学龙润普洱茶学院,云南 昆明 650201;
    2. 湖南农业大学教育部茶学重点实验室,湖南 长沙 410128;
    3. 云南省农业厅,云南 昆明 650201
  • 收稿日期:2008-07-18 修回日期:2008-11-17 出版日期:2009-02-15 发布日期:2019-09-06
  • 通讯作者: *larkin-liu@163.com
  • 作者简介:张冬英(1976— ),女,湖南常德人,讲师,博士,主要从事茶叶功能成分研究。
  • 基金资助:
    国家科技支撑计划课题(2007BAD58B04); 云南省科技厅项目(2006KJT-T02); 教育厅科学研究基金项目(07Y40163)

Research on the Anti-diabetes and Anti-hyperlipidenmia Function of Monomers in Pu-erh Tea

ZHANG Dong-ying1, SHAO Wan-fang1, LIU Zhong-hua2,*, LIU Ya-lin3, HUANG Ye-wei1   

  1. 1. College of Long Run Pu-erh Tea, Y N A U, Kunming 650201, China;
    2. Tea Key Lab of the Ministry of National Teaching, HNAU, Changsha 410128, China;
    3.Yunnan Agriculture Department, Kunming 650201, China
  • Received:2008-07-18 Revised:2008-11-17 Online:2009-02-15 Published:2019-09-06

摘要: 本文选取与糖脂代谢相关的PPARδ、PPARα、PPARγ、FXR、LXR、3T3-L1和α-淀粉酶模型,探讨了普洱茶中单体功能成分尿嘧啶、没食子酸的降糖降脂作用。结果表明:尿嘧啶、没食子酸在PPARγ、FXR、LXR模型表现出明显的活性作用,其中尤以没食子酸对PPARγ的激活效果最为显著,其值高达2.438,与阳性对照药物的激动效果相当,而对PPARδ、PPARα、3T3-L1模型的活性作用较弱。在PPARγ模型中,没食子酸对PPARγ受体的激活作用强于尿嘧啶,而在FXR、LXR模型中尿嘧啶的活性作用要强于没食子酸。此外,没食子酸对α-淀粉酶也有较强的抑制作用。本研究结果可为普洱茶的降糖降脂作用机理提供一定的理论依据。

关键词: 普洱茶, 没食子酸, 尿嘧啶, 降糖, 降脂

Abstract: The anti-diabetes and anti-hyperlipidenmia function of Uracil and Gallic acid from Pu-erh Tea was studied by the PPARδ, PPARα, PPARγ, FXR, LXR, 3T3-L1 and α-amylase models which are related to glucose and lipid metabolism. Result showed that: Uracil and gallic acid were active to the models of PPARγ, FXR, LXR, especially, Gallic acid showed distinct active effect on PPARγ, the value was as high as 2.438 which showed the same effect as positive drug, and weak activity on PPARδ, PPARα, 3T3-L1 models. Gallic acid showed better activity than Uracil in the PPARγ model and Uracil showed better activity than gallic acid in the FXR and LXR models. Furthermore, Gallic acid showed strongth inhibition on the activity of α-amylase. It can provide some theoretical basis on the mechanism of Pu-erh tea on the anti-diabetes and anti-hyperlipidenmia activity.

Key words: Pu-erh tea, gallic acid, uracil, anti-diabetes, anti-hyperlipidenmia

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