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Journal of Tea Science ›› 2003, Vol. 23 ›› Issue (2): 115-118.doi: 10.13305/j.cnki.jts.2003.02.006

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The Main Active Component of Lipophilic Tea Polyphenols and in vitro Inhibition Activity on Ovarian Cancer Cells HO-8910

CHEN Ping1,ZHONG Jian-hua1,SUN Dong2   

  1. 1. Department of Chemistry,Zhejiang University,Hangzhou 310028,China;
    2. Medical College of Wenzhou,Wenzhou 325000,China
  • Online:2003-11-25 Published:2019-09-16

Abstract: A single-substitution long-chain lipophilic catechin was isolated and purified from lipophilic tea polyphenols by high-speed countercurrent chromatography (HSCCC). Its molecular structure was elucidated as epigallocatechin-3-O-gallate-4'-palmitate by elemental analysis, IR, MS and 1H-NMR. The in vitro inhibition activity of the lipid-soluble epigallocatechin-3-O-gallate-4'-palmitate on ovarian cancer cells HO-8910 was investigated and compared with that of green tea polyphenols and lipophilic tea polyphenols. The results demonstrated that the inhibition activity of the single-substitution EGCG palmitate was almost corresponding to green tea polyphenols, and more effective than lipophilic tea polyphenols.

Key words: Tea science;Tea polyphenols;Lipophilic tea polyphenols;EGCG palmitate;HSCCC;Ovarian cancer cells;in vitro inhibition activity

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