To evaluate the edible safety of green tea buccal tablets(GTBT), tests included acute toxicity test, Aames test, Micronucleus test, Sperm shape abnormality test and thirty days feeding test were performed. Results shows that: The oral maximum tolerated dose(MTD) was higher than 20.0βg／kg·bw both in male or female mice and rats. Ames test, Micronucleus test and Sperm shape abnormality test were positive. No significant toxicity was detected in thirty days feeding test. Conclusion: Green tea buccal tablets has no acute toxicity, no genotoxicity, high in edible safety.
SU Mi-ju
,
WANG Yue-fei
,
LUO Yao-ping
,
LI Liang
,
YANG Xian-qiang
. Toxicological Research of the Edible Safety of Green Tea Buccal Tablets[J]. Journal of Tea Science, 2006
, 26(2)
: 122
-127
.
DOI: 10.13305/j.cnki.jts.2006.02.009
[1] 杨贤强, 王岳飞, 陈留记, 等. 茶多酚化学[M]. 上海: 上海科学技术出版社, 2003.
[2] 中华人民共和国卫生部. 保健食品检验与评价技术规范[M]. 2003.
[3] 党毅, 肖颖. 中药保健食品研制与开发[M]. 北京: 人民卫生出版社, 2002.
[4] 王岳飞. 茶儿茶素制剂毒理学安全性评价与保健功效研究[D]. 浙江: 浙江大学茶学系, 2004.
[5] Dufresne, Christiane J and Farnworth, Edward R. A review of latest research findings on the health promotion properties of tea[J]. Journal of Nutritional Biochemistry, Volume 12, Issue 7, July, 2001, Pages 404~421
[6] 王光亚. 保健食品功效成分检测方法[M]. 北京: 中国轻工业出版社, 2002.
[7] 付立杰. 现代毒理学及其应用[M]. 上海: 上海科学技术出版社, 2001.
[8] 刘毓谷. 卫生毒理学基础[M]. 北京: 人民卫生出版社, 1995.
浙公网安备 33019902000101号