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Review on Pro-oxidative Properties of EGCG on Cell

  • CHEN Yijun ,
  • XIONG Ligui ,
  • HUANG Jian′an ,
  • GONG Yushun ,
  • LIU Zhonghua
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  • 1. Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China;
    2. National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China;
    3. Collaborative Innovation Center of Utilization of Functional Ingredients from Botanicals, Hunan Agriculture University, Changsha 410128, China

Received date: 2014-12-18

  Revised date: 2015-02-03

  Online published: 2019-08-23

Abstract

EGCG, which is the most abundant catechin in tea, has been demonstrated to possess a wide range of biochemical and pharmacological activities. Recent investigations have revealed that EGCG functions as a pro-oxidant. In this review, we discussed the pro-oxidative mechanism of EGCG in cell culture. Auto-oxidation of EGCG, influenced by the media types, dose- and time-dependent of EGCG addition, contents of serum and pH value etc., forms environmental oxidative stress in cell medium. Furthermore, EGCG produce intracellular ROS and mtROS, and trigger the Fenton reaction to create OH- indirectly. In particular, pro-oxidation of EGCG regulate intracellular transcription factors, signalling pathways, and cell surface receptor to exert many biological actions in cell.

Cite this article

CHEN Yijun , XIONG Ligui , HUANG Jian′an , GONG Yushun , LIU Zhonghua . Review on Pro-oxidative Properties of EGCG on Cell[J]. Journal of Tea Science, 2015 , 35(2) : 130 -136 . DOI: 10.13305/j.cnki.jts.2015.02.004

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