Review on Pro-oxidative Properties of EGCG on Cell

CHEN Yijun; XIONG Ligui; HUANG Jian&#x02032;an; GONG Yushun; LIU Zhonghua

doi:10.13305/j.cnki.jts.2015.02.004

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Journal of Tea Science ›› 2015, Vol. 35 ›› Issue (2) : 130-136. DOI: 10.13305/j.cnki.jts.2015.02.004

Review on Pro-oxidative Properties of EGCG on Cell

CHEN Yijun¹, XIONG Ligui¹, HUANG Jian′an^1,2,3, GONG Yushun^1,*, LIU Zhonghua^1,2,3,*

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Abstract

EGCG, which is the most abundant catechin in tea, has been demonstrated to possess a wide range of biochemical and pharmacological activities. Recent investigations have revealed that EGCG functions as a pro-oxidant. In this review, we discussed the pro-oxidative mechanism of EGCG in cell culture. Auto-oxidation of EGCG, influenced by the media types, dose- and time-dependent of EGCG addition, contents of serum and pH value etc., forms environmental oxidative stress in cell medium. Furthermore, EGCG produce intracellular ROS and mtROS, and trigger the Fenton reaction to create OH^- indirectly. In particular, pro-oxidation of EGCG regulate intracellular transcription factors, signalling pathways, and cell surface receptor to exert many biological actions in cell.

Key words

auto-oxidation / biological activity / cell / EGCG / pro-oxidative / reactive oxidative species

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CHEN Yijun, XIONG Ligui, HUANG Jian′an, GONG Yushun, LIU Zhonghua. Review on Pro-oxidative Properties of EGCG on Cell[J]. Journal of Tea Science. 2015, 35(2): 130-136 https://doi.org/10.13305/j.cnki.jts.2015.02.004

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