Inhibition of Active Compounds in Tea on Melanin Formation

WANG Wei; CHEN Lin; WANG Weiwei; ZHANG Jianyong; JIANG Heyuan

doi:10.13305/j.cnki.jts.20201209.002

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Journal of Tea Science ›› 2021, Vol. 41 ›› Issue (1) : 7-18. DOI: 10.13305/j.cnki.jts.20201209.002

Review

Inhibition of Active Compounds in Tea on Melanin Formation

WANG Wei^1,2, CHEN Lin^1,2, WANG Weiwei¹, ZHANG Jianyong¹, JIANG Heyuan^1,*

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Abstract

Melanin is a kind of high molecular biological pigment. The color of skin is determined by the type and accumulation of melanin as well as the redistribution and degradation of melanosome. Solar ultraviolet radiation is the most common cause of melanin formation. Although melanin can protect skin cells from UV damage, the abnormal accumulation of melanin will lead to diseases related with melanin disorders. Therefore, the development of green, safe and efficient melanin inhibitors extracted from plants has become a research hotspot in recent years. Many studies have proved that extract or monomer compounds of tea could significantly inhibit (a) the activity of tyrosinase, (b) the growth, proliferation, infiltration and metastasis of melanocytes, (c) the occurrence of skin cancer. In this paper, the research progress of tea active compounds inhibiting melanin formation in acellular tyrosinase test system, cell test system, animal model and human skin was reviewed to fully explore the key active compounds, find a safe and efficient inhibitor of melanin synthesis and provide reference for the comprehensive utilization of tea products and increasing the added value of tea industry.

Key words

acellular tyrosinase test system / animal model / cell test system / human skin / melanin / tea active compounds

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WANG Wei, CHEN Lin, WANG Weiwei, ZHANG Jianyong, JIANG Heyuan. Inhibition of Active Compounds in Tea on Melanin Formation[J]. Journal of Tea Science. 2021, 41(1): 7-18 https://doi.org/10.13305/j.cnki.jts.20201209.002

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