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Journal of Tea Science ›› 2022, Vol. 42 ›› Issue (4): 447-462.doi: 10.13305/j.cnki.jts.2022.04.004

• Review •     Next Articles

Recent Advances in Catechin Biomedical Nanomaterials

YU Rongxin1,2,3, ZHENG Qinqin2,3, CHEN Hongping2,3, ZHANG Jinsong1,*, ZHANG Xiangchun2,3,*   

  1. 1. State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei 230036, China;
    2. Tea Research Institute, Chinese Academy of Agriculture Sciences, Hangzhou 310008, China;
    3. Key Laboratory of Tea Quality and Safety Control, Ministry of Agriculture and Rural Affairs, Hangzhou 310008, China
  • Received:2022-05-05 Revised:2022-06-07 Online:2022-08-15 Published:2022-08-23

Abstract: Catechins are a kind of bioactive substances rich in tea, which have the functions of anti-oxidation, anti-tumor, anti-virus, anti-inflammatory and immune regulation. However, due to the high activity of phenolic hydroxyl groups, catechins are easy to lose in vitro and in vivo activities, resulting in lower bioavailability. The recent development of nanobiotechnologies is expected to solve the problem of low bioavailability of catechins through ligand design, accurate synthesis and intelligent regulation, which can expand its application in the field of life and health. In this review, a summary on the progress of catechin biomedical nanomaterials in recent years, including the anti-tumor, antibacterial, anti-inflammatory, drug delivery and anti-virus activities, was firstly made. Later, the construction and biological mechanism of catechin biomedical nanomaterials were discussed in detail. Finally, future perspectives on the design and application of novel catechin nanomaterials were provided.

Key words: catechin, EGCG, nanomaterials, biomedicine, anti-tumor

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