表没食子儿茶素没食子酸酯预防并改善非酒精性脂肪性肝病的作用机制及研究进展

doi:10.13305/j.cnki.jts.2024.04.003

Abstract

Abstract: The incidence of nonalcoholic fatty liver disease (NAFLD) is increasing year by year and there is no specific drug available. The active ingredient of green tea, epigallocatechin gallate (EGCG), has been widely proven to have a favorable ameliorative effect on NAFLD in the low dose range. Some of the mechanisms by which EGCG delays the development of NAFLD through anti-oxidative stress, anti-inflammation, inhibition of iron death, reduction of lipogenesis, up-regulation of autophagy, modulation of intestinal flora, and reduction of bile acid metabolism were summarized in this paper, so as to provide insights for in-depth research on improving NAFLD.

Key words: nonalcoholic fatty liver disease, epigallocatechin gallate, oxidative stress, inflammation

CLC Number:

CHEN Jiaxin, ZHANG Jinjia, ZUO Huiling, JIAO Yuhang, SHI Anhua. The Mechanism and Research Progress of Epigallocatechin Gallate in Improving Non-alcoholic Fatty Liver Disease[J]. Journal of Tea Science, 2024, 44(4): 543-553.

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The Mechanism and Research Progress of Epigallocatechin Gallate in Improving Non-alcoholic Fatty Liver Disease

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[9]	HUANG Xiangxiang, YANG Zhe, YU Lijun. Research Progress of Green Tea and EGCG for the Prevention and Mitigation of Chronic Obstructive Pulmonary Disease Caused by Cigarette Smoke [J]. Journal of Tea Science, 2017, 37(4): 332-338.
[10]	ZHOU Ying, HUANG Qian, ZHANG Tian, CHEN Ping. Research on the Protective Effects of TFDG on IL-1β-induced Inflammatory Injury in Rat Chondrocytes in Vitro [J]. Journal of Tea Science, 2017, 37(3): 290-298.
[11]	QI Jie, XU Yinglei, LIANG Wenyi, FEI Duo, WU Xiner, JIN Jianchang, DU Qizhen, XU Yongquan, GAO Ying. Progress on the Preparation Technologies and the Active Improvement of EGCG Nano-carriers [J]. Journal of Tea Science, 2017, 37(2): 119-129.
[12]	GUO Chen, LIU Linfeng, XIANG Yi, LUO Li, LIN Ling, XIAO Wenjun. L-theanine Attenuates Tissue and Oxidative Damages in Heat Stressed Mice [J]. Journal of Tea Science, 2017, 37(1): 17-24.
[13]	ZHU Shengyi, TONG Yuling, ZHAO Yi, LÜ Haipeng, LIN Zhi, SHEN Guoli, SUN Ting, SONG Zhenya. Effect of Pu-erh Tea on Long Chain Fatty Acid Metabolism and Expression of Tight Junction Proteins in the Rat Model of Non-alcoholic Fatty Liver Disease [J]. Journal of Tea Science, 2016, 36(3): 237-244.
[14]	LIU Hongguo. The Investigation of the Protection Effects and Mechanism of EGCG on Kidney Ischemia Reperfusion Injury [J]. Journal of Tea Science, 2016, 36(2): 169-174.
[15]	LIU Xiaoxiang, SUN Aihua, DU Peng, CHEN Wenhu, ZHU Junli. Cross-resistance Induced by Tea Polyphenols in Pseudomonas aeruginosa [J]. Journal of Tea Science, 2015, 35(6): 534-542.