The Investigation of the Protection Effects and Mechanism of EGCG on Kidney Ischemia Reperfusion Injury

LIU Hongguo

doi:10.13305/j.cnki.jts.2016.02.007

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Journal of Tea Science ›› 2016, Vol. 36 ›› Issue (2) : 169-174. DOI: 10.13305/j.cnki.jts.2016.02.007

The Investigation of the Protection Effects and Mechanism of EGCG on Kidney Ischemia Reperfusion Injury

LIU Hongguo

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Abstract

The study aims to investigate potential protection and mechanism of epigallocatechin gallate（EGCG） on kidney ischemia reperfusion injury. The results showed that EGCG treatment improved renal dysfuction, pathlogical change of kidney tissues, and reduced the expression of Wnt3a, β-catenin, MDA, IL-6, IFN-γ and TNF-α, but increased the levels of CAT, GP_X and SOD, suggesting that EGCG can protect the kidney from ischemia-reperfusion injury in rats which is associated with suppressing the activation of Wnt/β-catenin/p53 signaling pathway and inhibiting inflammation and oxidative stress.

Key words

EGCG / inflammation / kidney ischemia reperfusion injury / oxidative stress / Wnt/β-catenin

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LIU Hongguo. The Investigation of the Protection Effects and Mechanism of EGCG on Kidney Ischemia Reperfusion Injury[J]. Journal of Tea Science. 2016, 36(2): 169-174 https://doi.org/10.13305/j.cnki.jts.2016.02.007

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