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Journal of Tea Science ›› 2024, Vol. 44 ›› Issue (5): 779-792.doi: 10.13305/j.cnki.jts.20240918.001

• Research Paper • Previous Articles     Next Articles

A Study on the Neuroprotective Effects of Combined EGCG and L-Theanine from Tea Leaves

DING Shuqia1,3, XIE Xinya1,3, LIU Zhusheng2,*, LIAO Xianjun2, LIU Zhonghua1,3, CAI Shuxian1,3,*   

  1. 1. National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Changsha 410128, China;
    2. Guangxi Research Institute of Tea Science, Guilin 541004, China;
    3. Key Lab of Education Ministry of Hunan Agricultural University for Tea Science, Changsha 410128, China
  • Received:2024-01-26 Revised:2024-03-25 Online:2024-10-15 Published:2024-11-08

Abstract: Differentiated neurons need to maintain axonal growth and function in a quiescent state. Previous studies have shown that epigallocatechin gallate (EGCG) and L-theanine can maintain the quiescent state of neurons and have neurorestorative effects, although the specific mechanisms are still unclear. In the Aβ25-35-induced PC12 cell damage model, combined treatment with EGCG and L-theanine improved cell metabolism and repair capacity, enhanced cell viability and showed a significant synergistic effect. Transcriptomic and network pharmacological analyses indicate that EGCG mainly maintains the quiescent state of cells by inhibiting oxidative stress, regulating fatty acid metabolism, and mitigating amyloid protein toxicity stress. L-theanine promotes axonal growth and regulates neuronal metabolism and synaptic function. The combined application of both compounds results in a broader and milder regulation of cellular networks, reducing cellular stress. This study provided theoretical support for the neuroprotective effects of tea and its value in an aging society.

Key words: EGCG, L-theanine, neuroprotection, network pharmacology, transcriptome, joint analysis

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