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Journal of Tea Science ›› 2020, Vol. 40 ›› Issue (4): 528-535.doi: 10.13305/j.cnki.jts.2020.04.009

• Research Paper • Previous Articles     Next Articles

Vardenafil Improves the Proliferative Inhibition of EGCG-β-lactoglobulin Nanoparticles Against Liver Cancer Cells

CHEN Chunxiao, LOU Wenyu, DING Zhenjian, LI Zhuoye, YANG Yuanyuan, JIN Peng, DU Qizhen*   

  1. School of Agricultural and Food Science, Zhejiang Agriculture and Forestry University, Hangzhou 311300, China
  • Received:2019-10-09 Revised:2020-04-11 Online:2020-08-15 Published:2020-08-18

Abstract: The combination of nano and other drugs is an important strategy to improve the biological activity of EGCG, since a high EGCG concentration is essential for the inhibition of the proliferation of cancer cells. In this study, EGCG-vardenafil (VD)-β-lactoglobulin (β-Lg)-nanoparticles (EVβ-NPs) was prepared by encapsulating EGCG and VD in β-Lg nano-carriers. In vitro experimental results show that EVβ-NPs could upgrade the activity of caspase-3 in HepG2 cells compared to the native EGCG, which caused cell cycle arrest in the S phase of HepG2 cells to induce cell nuclear division, and finally lead to HepG2 cell apoptosis. The results demonstrate that the encapsulation of EGCG-VD can significantly improve the anticancer activity of EGCG, and possesses potential value in the development of EGCG anticancer products.

Key words: EGCG, vardenafil, β-lactoglobulin, nanoparticles, proliferative inhibition

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