The Intergative Effects of Epigallocatechin-3-gallate and Vitamin C on Serum Uric Acid Levels in Hyperuricemic Mice

XU Yan; CAI Xiaqiang; XIE Qianjin; TAI Lingling; LIU Zenghui

doi:10.13305/j.cnki.jts.2020.03.011

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Journal of Tea Science ›› 2020, Vol. 40 ›› Issue (3) : 407-414. DOI: 10.13305/j.cnki.jts.2020.03.011

The Intergative Effects of Epigallocatechin-3-gallate and Vitamin C on Serum Uric Acid Levels in Hyperuricemic Mice

XU Yan^1,2, CAI Xiaqiang^1,2, XIE Qianjin^1,2, TAI Lingling^1,2, LIU Zenghui³

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Abstract

KM male mice were used as subjects of the study. Yeast extracts (7.5 g·kg^-1) and potassium oxonate (250 mg·kg^-1) were administered to establish the hyperuricemic mice model. The study aimed to investigate the integrative effect of EGCG and vitamin C (Vc) on serum uric acid levels of hyperuricemic mice. Mice were randomly divided into 6 groups (n=6): blank group, model group, allopurinol group, EGCG group, EGCG + Vc group and Vc group. The biochemical indexes of mice were measured after 7 d of continuous administration. The results show that the serum uric acid (UA), serum urea nitrogen (BUN) and creatinine (Cr) of EGCG + Vc group were significantly lower than those of the model group (P<0.001). The combination of EGCG and Vc could remarkably inhibited the activities of adenosine deaminase (ADA) and xanthine oxidase (XOD) in the liver (P<0.05 or P<0.01) and significantly down-regulated the expression of glucose transporter 9 (GLUT9) in the kidney (P<0.001). The results of kidney slices indicated that EGCG + Vc could obviously improve the damages to the kidney in hyperuricemic mice. In addition, the integrative effect of EGCG + Vc on hyperuricemic mice was better than that of EGCG.

Key words

ascorbic acid / EGCG / GLUT9 / hyperuricemia / serum UA

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XU Yan, CAI Xiaqiang, XIE Qianjin, TAI Lingling, LIU Zenghui. The Intergative Effects of Epigallocatechin-3-gallate and Vitamin C on Serum Uric Acid Levels in Hyperuricemic Mice[J]. Journal of Tea Science. 2020, 40(3): 407-414 https://doi.org/10.13305/j.cnki.jts.2020.03.011

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