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茶叶科学 ›› 2007, Vol. 27 ›› Issue (4): 307-310.doi: 10.13305/j.cnki.jts.2007.04.008

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茯茶毒理学试验报告

肖文军1, 2, 傅冬和1, 2, 任国谱3, 龚志华1, 萧力争1, 刘仲华1, 2, *   

  1. 1. 湖南农业大学园艺园林学院,湖南 长沙 410128;
    2. 教育部茶学重点实验室,湖南 长沙 410128;
    3. 中南林业科技大学食品科学与工程学院,湖南 长沙 410004
  • 收稿日期:2007-05-10 修回日期:2007-06-27 出版日期:2007-12-25 发布日期:2019-09-11
  • 通讯作者: * 刘仲华
  • 作者简介:肖文军(1969— ),男,湖南城步人,博士,副研究员,主要从事植物功能成分的分离纯化工程研究。
  • 基金资助:
    基金课题:国家十一五支撑计划农牧交错区奶牛养殖技术规范建立与高产核心牛群构建课题(2006BAD04A15)

Study on the Toxicity Experiments of Fuzhuan Tea

XIAO Wen-jun1, 2, FU Dong-he1, 2, REN Guo-pu3, GONG Zhi-hua1, XIAO Li-zheng1, LIU Zhong-hua1, 2, *   

  1. 1. Horticulture and Landscape College of Hunan Agricultural University, ChangSha 410128, China;
    2. Tea Key Lab of the Ministry of National Teaching of Hunan Agricultural University, ChangSha 410128, China;
    3. Food Science and Engineering College of Central South Forestry University, ChangSha 410004, China
  • Received:2007-05-10 Revised:2007-06-27 Online:2007-12-25 Published:2019-09-11

摘要: 以提制的速溶茯茶为原料,采用药物毒理学试验方法,研究了速溶茯茶对小鼠与大鼠的毒理特性。结果表明,茯茶对雄性小鼠的急性经口LD50为14β700βmg/kg·bw,对雌性小鼠的急性经口LD50为19β600βmg/kg·bw(95%可信限为10β600~36β000),Ames及致小鼠精子畸形试验均为阴性。以含0.85%、1.25%、1.70%速溶茯茶的饲料喂饲大鼠30βd,各组大鼠生长发育良好,各剂量组对雌雄鼠血像、雄鼠血生化各项、甘油三酯、尿素酐、血肌酐、血糖和雌雄鼠脾/体、肾/体比值、组织病理均无显著影响(P<0.05),表明茯茶实际属无毒物。

关键词: 茯茶, 茯砖茶, 毒性试验, 半致死量

Abstract: The toxic experiment of Fuzhuan tea was carried out by using the extracted instant Fuzhuan tea as material in order to evaluate its safety for the mice and rat. The results showed that the LD50 of male mice and female mice was 14β700βmg/kg·bw and 19β600βmg/kg·bw respectively(the limit reliability was 10β600~36β000), and both of the Ames test and the semen teratogenicity results were negative. During the 30 days fed by the feeding mixed with 0.85%, 1.25%, 1.70% instant Fuzhuan Tea for the rat rats of each dose group grew well, the hemogram indexes of rats from each dosage, blood biochemical indexes and triglyceride, Urea anhydride, blood muscle anhydride and blood sugar indexes, ratio of spleen to body weight, kidney to body weight, and the histopathological characteristic of all test rats showed no significantly difference (P<0.05), which suggested Fuzhuan Tea was a no poisonous food.

Key words: Fuzhuan Tea, Fuzhuan brick tea, toxity experiment, LD50

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