关键词: 红茶, 发花红砖茶, 高尿酸血症, 模型小鼠, 降尿酸作用

Abstract: Based on the successful establishment of hyperuricemia model mice by potassium oxonate, black tea and its flower black brick tea made from the same fresh leaves were used to investigate their effects on lowering uric acid in hyperuricemic mice. In the study, ninety KM male mice were randomly divided into nine groups (10 mices for each group) including the normal group, the model group, the black tea-treated groups (high dose, middle dose, low dose) and the allopurinol group. Then all mice were orally administrated for fourteen days. The results showed that compared with the model group, the levels of weight , kidney index and serum uric acid in tea-treated groups were significantly decreased (P＜0.05). Moreover, the high-dose group of flower black brick tea had extremely significant reduction in blood uric acid (P<0.01). Blood urea nitrogen and serum creatinine also decreased significantly in tea-treated groups (P<0.01). The levels of urine urea nitrogen in the middle and high dose groups increased significantly (P<0.01), and the levels of urine uric acid in the high dose groups increased significantly (P<0.01). The levels of urine creatinine were significantly increased in the tea-treated groups (P<0.01) except the low-dose black tea group which showed an opposite trend (P<0.05). The middle dose group of flower black brick tea significantly decreased the activities of xanthine oxidase and adenosine deaminase (P<0.05). The middle dose group of black tea and both high dose groups all highly significantly reduced the activities of these two enzymes (P<0.01). These results showed that black tea and flower black brick tea could reduce the production of uric acid, and the high-dose flower black brick tea group was superior to black tea in lowering blood uric acid and increasing uric acid, urine urea nitrogen, and urine creatinine. The mechanism remains to be further explored.

Key words: black tea, flower black brick tea, hyperuricemic, model mice, lowering uric acid