茶多酚改善胰岛素抵抗的初步研究

doi:10.13305/j.cnki.jts.2014.02.006

茶叶科学 ›› 2014, Vol. 34 ›› Issue (2): 144-148.doi: 10.13305/j.cnki.jts.2014.02.006

茶多酚改善胰岛素抵抗的初步研究

夏家杰, 薛蒙, 金梦, 吴珏莅, 刘含登^*

重庆医科大学实验教学管理中心,重庆 400016

收稿日期:2013-07-08 修回日期:2013-09-04 出版日期:2014-04-15 发布日期:2019-09-03
通讯作者: *rd-liuhandeng@163.com
作者简介:夏家杰（1992— ）,男,浙江绍兴人,硕士研究生,主要从事糖尿病研究。
基金资助:
2012年重庆医科大学大学生科研与创新实验项目（No. 201220）

Preliminary Reserch of Tea Polyphenols on Insulin Resistance

XIA Jiajie, XUE Meng, JIN Meng, WU Jueli, LIU Handeng^*

Experimental Teaching Center of Chongqing Medical University, Chongqing 400016, China

Received:2013-07-08 Revised:2013-09-04 Online:2014-04-15 Published:2019-09-03

摘要/Abstract

摘要： 研究了茶多酚（Tea Polyphenols,TP）降低肝脏中甘油三酯（Triglyceride, TG）含量从而对2型糖尿病性脂肪肝模型大鼠胰岛素抵抗的改善作用。健康SD大鼠分为6组：健康组、模型组、TP组、二甲双胍组、FL组和FL+TP组。所有大鼠在实验结束时测量体重、血清甘油三酯、肝脏中甘油三酯、空腹血糖、血清胰岛素等指标。TP组和二甲双胍组较模型组空腹血糖、血清胰岛素含量和胰岛素敏感指数下降;FL+TP组、TP组较FL组、模型组肝脏中甘油三酯含量下降。茶多酚可显著降低肝脏中的甘油三酯含量,调节脂代谢紊乱并改善胰岛素抵抗。

关键词: 茶多酚, 胰岛素抵抗, 甘油三酯, 2型糖尿病

Abstract: To study the effects of tea polyphenols (TP) on insulin resistance in the model rats of T2DM with NAFLD and its mechanism. Adult healthy SD rats were randomly divided into six equal groups: normal control (NC) group, model group, TP group, metformin group, fat liver (FL) group and FL+TP group. In the end of two weeks treatment, the levels of fasting serum glucose, insulin, TG and the TG of liver were measured. Two weeks after treatment, the fasting blood glucose and insulin and insulin sensitivity index of the TP group and metformin group were both significantly lower than those of the model group (both P<0.05). The TP group and FL+TP group compared with model group and FL group, the TP significantly reduce the levels of TG of the liver (both P<0.05). TP can efficiently ameliorated lipid metabolism in the liver tissue of rats and improve insulin sensitivity in the rat model of type 2 diabetes mellitus with fatty liver.

Key words: tea polyphenols, insulin resistance, triglyceride, T2DM

中图分类号:

夏家杰, 薛蒙, 金梦, 吴珏莅, 刘含登. 茶多酚改善胰岛素抵抗的初步研究[J]. 茶叶科学, 2014, 34(2): 144-148. doi: 10.13305/j.cnki.jts.2014.02.006.

XIA Jiajie, XUE Meng, JIN Meng, WU Jueli, LIU Handeng. Preliminary Reserch of Tea Polyphenols on Insulin Resistance[J]. Journal of Tea Science, 2014, 34(2): 144-148. doi: 10.13305/j.cnki.jts.2014.02.006.

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茶多酚改善胰岛素抵抗的初步研究

Preliminary Reserch of Tea Polyphenols on Insulin Resistance

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