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Journal of Tea Science ›› 2008, Vol. 28 ›› Issue (1): 39-42.doi: 10.13305/j.cnki.jts.2008.01.006

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Investigation on the Function of Monomers in Fuzhuan Tea by High-Throughput Screening

FU Dong-he1,2, LIU Zhong-hua1,2,*, HUANG Jian-an1,2, CHEN Jin-hua1, CHEN Hui-heng2   

  1. 1. Tea Key Lab of the Ministry of National Teaching, Hunan Agricultural University, ChangSha 410128, China;
    2. College of Horticulture and Landscape, Hunan Agricultural University, ChangSha 410128, China
  • Received:2007-07-31 Revised:2007-11-16 Online:2008-02-15 Published:2019-09-16

Abstract: Six compounds separated from Fuzhuan Tea were tested by High-Throughput Screening of model FXR, LXR, PPARδ, PPARγ and 3T3-L1 related to the lipid-depressing and anti-obesity. Results showed that all monomers were active to the models selected. To the active model FXR, gallic acid and ECG were active on the concentration of 50 µg/ml. The activating value of GA and ECG was 1.766 and 3.220 respectively. EGCG was very active on the concentration of 10 µg/ml and 50 µg/ml. The active value reached 6.0 when the concentration was 50 µg/ml. To PPARδ, the three compounds were active when the concentration was 50 µg/ml. The activating value of GC to PPARγ model was 1.619. The activating value of 3- methoxy- 4,5-dihydroxy-benzoic acid in PPARγ model was 1.734. The restraining value of 3,4-dihydroxy-benzoic acid in FXR model was 3.641, while that of CDCA(CK) was 6.435. All the results showed that all the compounds were functional ones.

Key words: Fuzhuan Tea, monomer, high-throughput screening, therapy hyperlipidemia and adiposity

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