茶多酚与油菜花粉提取物对前列腺癌细胞生长抑制效果比较研究

doi:10.13305/j.cnki.jts.2010.05.009

Abstract

Abstract: To study the effect of tea polyphenols (TP) or rape pollen extract (RPE) on the inhibition of PC-3 cell in vitro. MTT assay was used to evaluate the inhibition activity (IC₅₀) on PC-3 proliferation, and fluorescence microscope was used to observe the apotosis cells. Results showed that water-soluble extract of pollen (A), ethanol-soluble pollen extract (B) and TP were proved to be effectively inhibited on the prostate cancer cell PC-3. The IC₅₀ of A, A+TP, B+TP and TP were 1470, 752, 82 μg/mL and 45 μg/mL, respectively. B+TP showed effect-dose and effect-time relationship. B+TP was also found to induce cell apotosis as shown by changes in nuclear morphology and DNA fragmentation.

Key words: tea polyphenols (TP), rape pollen extract (RPE), prostate cancer, apotosis

CLC Number:

ZHANG Xing-hai, GONG Shu, WANG Yue-fei, ZHOU Xiao-hong. Comparation on the Inhibitory Effect of Tea Polyphenols and Rape Pollen Extract on Prostate Cancer Cell[J]. Journal of Tea Science, 2010, 30(5): 379-383.

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Comparation on the Inhibitory Effect of Tea Polyphenols and Rape Pollen Extract on Prostate Cancer Cell

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