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Journal of Tea Science ›› 2021, Vol. 41 ›› Issue (4): 525-534.doi: 10.13305/j.cnki.jts.2021.04.006

• Research Paper • Previous Articles     Next Articles

A Study of Xinyang Maojian Tea Water Extracts on Relieving Lung Injury Caused by PM2.5

LIU Jianjun1,2,3, LI Meifeng3, ZHANG Jing1,2,3, TIAN Lili1,2,4, DENG Yanli1,2,3, LIN Haiyan1,2, HUANG Jian′an1,2,*, LIU Zhonghua1,2,*   

  1. 1. Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China;
    2. National Research Center of Engineering & Technology for Utilization of Functional Ingredients from Botanicals, Changsha 410128, China;;
    3. Tea College, Guizhou University, Guiyang 550025, China;
    4. Shandong Institute of Pomology, Taian 271000, China
  • Received:2021-05-08 Revised:2021-06-01 Online:2021-08-15 Published:2021-08-12

Abstract: In this study, the healthy male sprague-dawley (SD) rats were taken as experimental subjects, and the water extracts of Xinyang Maojian tea were used as test substances, while intratracheal instillation of PM2.5 suspension was established as chronic pulmonary injury model. Rats serum and biochemical indexes of bronchoalveolar lavage fluid (BALF) were tested. The results show that the tea extracts had antagonism effects on the reduce of rats growth rate and the lung injury caused by PM2.5. Furthermore, the tea water extracts could effectively lower the increase of IL-1β, IL-6, TNF-α, IgG and the activity of LDH, and keep the activity of SOD in rats serum and BALF, showing a dose-dependent effects.

Key words: Xinyang Maojian tea, alleviate, fine particulate matter, intratracheal instillation, pulmonary injury

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