The effect of black tea extracts on extending the lifespan of Caenorhabditis elegans nematode under Oxidative stress was studied by the authors. Results showed the mean lifespan was significantly extended upon the concentration of 50βmg/L black tea extract treatment under oxidative stress. Further studies demonstrated that the significant up-regulation of stress-resistance-related enzyme including superoxide dismutase-3 (SOD-3) by 40.8% and GSH-Px by 340.8%,and its up-regulation of stress-resistance-related proteins, including SKN-1::GFP by 10% and DAF-16::GFP by 18%. These results indicate that black tea extracts can extend the lifespan of Caenorhabditis elegans nematode against oxidative stress.
ZHANG Jian-wei
,
XIONG Zhe
,
GAO Yan
,
PENG Yu-xuan
,
GONG Yu-shun
,
LIU Zhong-hua
. Black Tea Extend the Lifespan of Caenorhabditis elegans Nematode under Oxidative Stress[J]. Journal of Tea Science, 2013
, 33(4)
: 295
-300
.
DOI: 10.13305/j.cnki.jts.2013.04.002
[1] Sies H, Jones DP.Oxidative Stress[C]//Fink G. Encyclopaedia of stress. San Diego: Elsevier, 2007: 45-48.
[2] Reuter S, Gupta SC, Chaturvedi MM, et al. Oxidative stress, inflammation, and cancer: how are they linked?[J]. Free Radic Biol Med, 2010, 49(11): 1603-1616.
[3] Rodrigo R.Oxidative stress and antioxidants: their role in human disease[M]. Chile: Nova Science Pub Incorporated, 2009.
[4] Benz CC, Yau C.Ageing, oxidative stress and cancer: paradigms in parallax[J]. Nat Rev Cancer, 2008, 8(11): 875-879.
[5] Mustafa Zakkar, Kim Van der Heiden, Le Anh Luong, et al. Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state[J]. Arterioscler Thromb Vasc Biol, 2009, 29(11): 1851-1857.
[6] Kitada M, Kume S, Imaizumi N, et al. Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway[J]. Diabetes, 2011, 60(2): 634-643.
[7] ZHANG LZ, JIE GL, ZHANG JJ, et al. Significant longevity- extending effects of EGCG on Caenorhabditis elegans under stress[J]. Free Radic Biol Med, 2009, 46(3): 414-421.
[8] Jae Hyung An, T Keith Blackwell. SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response[J]. Genes, 2003, 17: 1882-1893.
[9] F A C Wiegant.S, Surinova.E, Ytsma.M, et al. Post Plant adaptogens increase lifespan and stress resistance in C. elegans [J]. Biogerontology, 2009, 10: 27-42.
[10] Kraynov V S, Chamberlain C, Bokoch G M, et al. Localized Rac activation dynamics visualized in living cells[J]. Science, 2000, 290: 333-337.
[11] Strayer A, Wu Z, Christen Y, et al. Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761[J]. FASEB J, 2003, 17: 2305-2307.
[12] Henderson ST, Johnson TE.Daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans[J]. Curr Biol, 2001(1): 1975-1980.
[13] Liao VH, Yu CW.Caenorhabditis elegans gsc-1 confers resistance to arsenic-induced oxidative stress[J]. Biometals, 2005, 18: 519-528.
浙公网安备 33019902000101号