儿茶素生物医用纳米材料研究进展

俞蓉欣; 郑芹芹; 陈红平; 张劲松; 张相春

doi:10.13305/j.cnki.jts.2022.04.004

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茶叶科学 ›› 2022, Vol. 42 ›› Issue (4) : 447-462. DOI: 10.13305/j.cnki.jts.2022.04.004

综述

儿茶素生物医用纳米材料研究进展

俞蓉欣^1,2,3, 郑芹芹^2,3, 陈红平^2,3, 张劲松^1,*, 张相春^2,3,*

作者信息 +

Recent Advances in Catechin Biomedical Nanomaterials

YU Rongxin^1,2,3, ZHENG Qinqin^2,3, CHEN Hongping^2,3, ZHANG Jinsong^1,*, ZHANG Xiangchun^2,3,*

Author information +

文章历史 +

摘要

儿茶素具有抗氧化、抗肿瘤、抗病毒、抗炎和免疫调节等功能,是茶叶中含量丰富的一类生物活性物质。由于酚羟基的高活泼性导致儿茶素在生物体外及体内极易失去活性,致使其在生物体内利用度不高。近年来,纳米生物技术的发展有望通过配体设计、精准合成和智能调控等策略解决儿茶素低生物利用度的难题,并拓展其在生命健康领域中的应用。综述了近几年儿茶素生物医用纳米材料的研究进展,重点阐述了儿茶素生物医用纳米材料的抗肿瘤、抗菌、抗炎、药物递送和抗病毒等活性,对儿茶素生物医用纳米材料的构建和生物作用机制进行了探讨,并对儿茶素新材料设计及其应用前景进行了展望。

Abstract

Catechins are a kind of bioactive substances rich in tea, which have the functions of anti-oxidation, anti-tumor, anti-virus, anti-inflammatory and immune regulation. However, due to the high activity of phenolic hydroxyl groups, catechins are easy to lose in vitro and in vivo activities, resulting in lower bioavailability. The recent development of nanobiotechnologies is expected to solve the problem of low bioavailability of catechins through ligand design, accurate synthesis and intelligent regulation, which can expand its application in the field of life and health. In this review, a summary on the progress of catechin biomedical nanomaterials in recent years, including the anti-tumor, antibacterial, anti-inflammatory, drug delivery and anti-virus activities, was firstly made. Later, the construction and biological mechanism of catechin biomedical nanomaterials were discussed in detail. Finally, future perspectives on the design and application of novel catechin nanomaterials were provided.

导出引用

俞蓉欣, 郑芹芹, 陈红平, 张劲松, 张相春. 儿茶素生物医用纳米材料研究进展[J]. 茶叶科学. 2022, 42(4): 447-462 https://doi.org/10.13305/j.cnki.jts.2022.04.004

YU Rongxin, ZHENG Qinqin, CHEN Hongping, ZHANG Jinsong, ZHANG Xiangchun. Recent Advances in Catechin Biomedical Nanomaterials[J]. Journal of Tea Science. 2022, 42(4): 447-462 https://doi.org/10.13305/j.cnki.jts.2022.04.004

中图分类号： S571.1 Q946.84+1

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