饮用金花香橼茶3个月对小样本高脂血症人群糖脂代谢的改善效果研究

孙颖; 陈鑫; 杨华; 应剑; 邵丹青; 吕晓华; 肖杰; 陈志雄; 李颂; 覃俊杰; 郑斌; 高建设

doi:10.13305/j.cnki.jts.2022.04.010

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茶叶科学 ›› 2022, Vol. 42 ›› Issue (4) : 561-576. DOI: 10.13305/j.cnki.jts.2022.04.010

研究报告

饮用金花香橼茶3个月对小样本高脂血症人群糖脂代谢的改善效果研究

孙颖^1,3,4, 陈鑫^1,3,4, 杨华², 应剑^1,3,4, 邵丹青^1,3,4,*, 吕晓华^2,*, 肖杰^1,3,4, 陈志雄⁵, 李颂⁶, 覃俊杰⁷, 郑斌⁵, 高建设⁵

作者信息 +

Clinical Trial on the Effect of Drinking Jinhua Xiangyuan Tea for 3 Months on the Improvement of Glucose and Lipid Metabolism in A Small Sample Hyperlipidemia Population

SUN Ying^1,3,4, CHEN Xin^1,3,4, YANG Hua², YING Jian^1,3,4, SHAO Danqing^1,3,4,*, LÜ Xiaohua^2,*, XIAO Jie^1,3,4, CHEN Zhixiong⁵, LI Song⁶, QIN Junjie⁷, ZHENG Bin⁵, GAO Jianshe⁵

Author information +

文章历史 +

摘要

探讨一款用黑茶工艺、经冠突散囊菌发花的乌龙茶——金花香橼茶饮用3个月对小样本高脂血症人群糖脂代谢的临床改善效果。招募38名志愿者,试饮金花香橼茶3个月,通过检测和对比试饮前后的体成分（体重、体脂百分比等）、血液生化指标（空腹血糖、血尿酸、血脂四项）、肝脏超声、肠道菌群等,探讨金花香橼茶的健康功效。结果表明,试饮金花香橼茶3个月后,志愿者体重、体质指数、体脂百分比、内脏脂肪等级、血清总胆固醇、低密度脂蛋白胆固醇、空腹血糖显著降低（P<0.05）,脂肪肝严重程度减轻,肠道菌群均匀性和多样性增加,考拉杆菌属（Phascolarctobacterium）、瘤胃球菌属（Ruminococcus）、嗜血杆菌属（Haemophilus）、韦荣球菌属（Veillonella）等丰度升高,戴阿利斯特杆菌属（Dialister）、丁酸蓖麻单胞菌属（Butyricimonas）丰度降低。提示金花香橼茶具有辅助降血糖、降血脂、改善非酒精性脂肪肝的作用,可能通过增加产短链脂肪酸菌属的丰度,增加短链脂肪酸,改善胰岛素抵抗,进而改善糖脂代谢。本研究所得结果仍需更加严谨的长期试验进一步加以确证。

Abstract

This study is aimed at investigating the clinical effect of drinking Jinhua Xiangyuan tea for 3 months on the glucose and lipid metabolism in a small sample patients with hyperlipidemia (with/without non-alcoholic fatty liver). Jinhua Xiangyuan tea was produced by the new process using Eurotium cristatum. In this study, before-and-after control design was used. The body composition (body weight, BMI, waist hip ratio, percentage of body fat, visceral fat grade), blood biochemical indicators (fasting blood glucose, uric acid, blood lipid), fatty liver, and gut microbiota were examined before and after the test. After drinking Jinhua Xiangyuan tea for 3 months, the body weight, BMI, percentage of body fat, visceral fat grade, serum total cholesterol, low-density lipoprotein cholesterol, and fasting blood glucose of 38 volunteers were significantly reduced (P<0.05). Fatty liver was less severe. Gut microbiota’s diversity and richness were increased. The relative abundance of Phascolarctobacterium, Ruminococcus, Haemophilus and Veillonella were increased, and Dialister and Butyricimonas were decreased. Jinhua Xiangyuan tea could increase the relative abundance of short-chain fatty acid-producing bacteria, increasing short-chain fatty acids, and improving insulin resistance, then improving glucose and lipid metabolism. The results of this study still need to be further confirmed by more rigorous long-term experimental observation.

导出引用

孙颖, 陈鑫, 杨华, 应剑, 邵丹青, 吕晓华, 肖杰, 陈志雄, 李颂, 覃俊杰, 郑斌, 高建设. 饮用金花香橼茶3个月对小样本高脂血症人群糖脂代谢的改善效果研究[J]. 茶叶科学. 2022, 42(4): 561-576 https://doi.org/10.13305/j.cnki.jts.2022.04.010

SUN Ying, CHEN Xin, YANG Hua, YING Jian, SHAO Danqing, LÜ Xiaohua, XIAO Jie, CHEN Zhixiong, LI Song, QIN Junjie, ZHENG Bin, GAO Jianshe. Clinical Trial on the Effect of Drinking Jinhua Xiangyuan Tea for 3 Months on the Improvement of Glucose and Lipid Metabolism in A Small Sample Hyperlipidemia Population[J]. Journal of Tea Science. 2022, 42(4): 561-576 https://doi.org/10.13305/j.cnki.jts.2022.04.010

中图分类号： S571.1 TS272.5+5

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