[1] 陈宗懋. 2000年茶业展望[J]. 茶叶科学, 1994, 14(2): 81-88. [2] 刘本英, 王平盛. 茶多酚生物学活性的研究进展[J]. 中国农学通报, 2005, 29(2): 28-33. [3] Camargo AEI, Daguer DAE, Barbosa DS.Green tea exerts antioxidant action in vitro and its consumption increases total serum antioxidant potential in normal and dyslipidemic subjects[J]. Nutrition Research, 2006, 26(12): 626-631. [4] Higdon JV, Frei B.Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions. Critical Reviews in Food Science and Nutrition[J]. 2003, 43(1): 89-143. [5] Erba D, Riso P, Bordoni A, et al. Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans[J]. The Journal of Nutritional Biochemistry, 2005, 16(3): 144-149. [6] Siddiqui IA, Asim M, Hafeez BB, et al. Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer[J]. The FASEB Journal, 2011, 25(4): 1198-1207. [7] 查龙应, 许梓荣, 王敏奇. Caco-2细胞模型及其在营养素小肠吸收机理研究中的应用[J]. 动物营养学报, 2006, 18(3): 215-222. [8] Shimizu M.Modulation of intestinal functions by food substances[J]. Nahrung-Food, 1999, 43(3): 154-158. [9] Langerholc T, Maragkoudakis PA, Wollgast J, et al. Novel and established intestinal cell line models - An indispensable tool in food science and nutrition[J]. Trends in Food Science & Technology, 2011, 22(S1): S11-S20. [10] van Breemen RB, Li Y. Caco-2 cell permeability assays to measure drug absorption[J]. Expert Opinion on Drug Metabolism & Toxicology, 2005, 1(2): 175-185. [11] Shah P, Jogani V, Bagchi T, et al. Role of Caco-2 cell monolayers in prediction of intestinal drug absorption[J]. Biotechnology Progress, 2006, 22(1): 186-198. [12] Hubatsch I, Ragnarsson EGE, Artursson P.Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers[J]. Nature Protocols, 2007, 2(9): 2111-2119. [13] Shimizu M.Interaction between food substances and the intestinal epithelium[J]. Bioscience Biotechnology and Biochemistry, 2010, 74(2): 232-241. [14] 赵艳红, 贾晓斌, 陈彦, 等. Caco-2细胞模型及其对黄酮类成分作用机制研究进展[J]. 中草药, 2007, 38(6): 938-941. [15] 陈留记, 杨贤强, 金明向. 茶儿茶素代谢动力学研究进展[J]. 茶叶科学, 2000, 20(1): 11-16. [16] Artursson P, Palm K, Luthman K.Caco-2 monolayers in experimental and theoretical predictions of drug transport[J]. Advanced Drug Delivery Reviews, 1996, 22(1/2): 67-84. [17] Chan KY, Zhang L, Zuo Z.Intestinal efflux transport kinetics of green tea catechins in Caco-2 monolayer model[J]. Journal of Pharmacy and Pharmacology, 2007, 59(3): 395-400. [18] Konishi Y, Kobayashi S, Shimizu M.Tea polyphenols inhibit the transport of dietary phenolic acids mediated by the monocarboxylic acid transporter (MCT) in intestinal Caco-2 Cell monolayers[J]. Journal of Agricultural and Food Chemistry, 2003, 51(25): 7296-7302. [19] Kosińska A, Xie Y, Diering S, et al. Stability of phenolic compounds isolated from cocoa, green tea and strawberries in Hank's balanced salt solution under cell culture conditions[J]. Polish Journal of Food and Nutrition Science, 2012, 62(2): 91-96. [20] Feng WY.Metabolism of green tea catechins: An overview[J]. Current Drug Metabolism, 2006, 7(7): 755-809. [21] 顾成波, 袁肖寒, 付玉杰, 等. 绿茶EGCG防癌作用的分子靶点[J]. 茶叶科学, 2010, 30(6): 414-422. [22] 郭子涛. 表没食子儿茶素没食子酸酯(EGCG)在Caco-2细胞中的摄取、跨膜转运和外排研究[D]. 上海: 华东师范大学, 2011. [23] Vaidyanathan JB, Walle T.Transport and metabolism of the tea flavonoid (-)-epicatechin by the human intestinal cell line Caco-2[J]. Pharmaceutical Research, 2001, 18(10): 1420-1425. [24] Vaidyanathan JB, Walle T.Cellular uptake and efflux of the tea flavonoid (-)-epicatechin-3-gallate in the human intestinal cell line Caco-2[J]. Journal of Pharmacology and Experimental Therapeutics, 2003, 307(2): 745-752. [25] Zhang L, Zheng Y, Chow MSS, et al. Investigation of intestinal absorption and disposition of green tea catechins by Caco-2 monolayer model[J]. International Journal of Pharmaceutics, 2004, 287(1-2): 1-12. [26] Zhang L, Chow MSS, Zuo Z.Effect of the co-occurring components from green tea on the intestinal absorption and disposition of green tea polyphenols in Caco-2 monolayer model[J]. Journal of Pharmacy and Pharmacology, 2006, 58(1): 37-44. [27] Peters CM, Green RJ, Janle EM, et al. Formulation with ascorbic acid and sucrose modulates catechin bioavailability from green tea[J]. Food Research International, 2010,43(1): 95-102. [28] Xie YL, Kosińska A, Xu H, et al. Milk enhances intestinal absorption of green tea catechins in in vitro digestion/Caco-2 cells model[J/OL]. Food Research International, 2012. http://dx.doi.org/10.1016/j.foodres.2012.07.063. [29] Kitaoka S, Hayashi H, Yokogoshi H, et al. Transmural potential changes associated with the in vitro absorption of theanine in the guinea pig intestine[J]. Bioscience, Biotechnology, and Biochemistry, 1996, 60(11): 1768-1771. [30] 吕亚宁. 茶叶中主要特征成分在Caco-2细胞模型中吸收情况的研究[D]. 合肥: 安徽农业大学, 2010. [31] 李肖玲, 崔岚, 祝徳秋. 没食子酸生物学作用的研究进展[J]. 中国药师, 2007, 7(10): 767-769. [32] Konishi Y, Kobayashi S, Shimizu M.Transepithelial transport of p-coumaric acid and gallic acid in Caco-2 cell monolayers[J]. Bioscience, Biotechnology, and Biochemistry, 2003, 67(11): 2317-2324. [33] 宛晓春. 茶叶生物化学[M]. 3版. 北京: 中国农业出版社, 2003: 39. [34] Williamson G, Day AJ, Plumb GW, et al. Human metabolic pathways of dietary flavonoids and cinnamates[J]. Biochemical Society Transactions, 2000, 28(2): 16-22. [35] Neilson AP, Ferruzzi MG.Influence of formulation and processing on absorption and metabolism of flavan-3-Ols from tea and cocoa[J]. Annual Review of Food Science and Technology, 2011, 2: 125-151. [36] Vaidyanathan JB, Walle T.Glucuronidation and sulfation of the tea flavonoid (-)-epicatechin by the human and rat enzymes[J]. Drug metabolism and disposition, 2002, 30(8): 897-903. [37] Johnston K, Sharp P, Clifford M, et al. Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells[J]. FEBS Letters, 2005, 579(7): 1653-1657. [38] Shimizu M, Kobayashi Y, Suzuki M, et al. Regulation of intestinal glucose transport by tea catechins[J]. Biofactors, 2000, 13(1/2/3/4): 61-65. [39] 张海凤, 董亚琳, 张琰. 没食子酸的α-葡萄糖苷酶抑制作用及降糖机制研究[C]. //中国药学会. 2010年中国药学大会暨第十届中国药师周论文集. 2010: 192-195. [40] 缪小平, 林东昕. 叶酸与肿瘤[J]. 癌症, 2003, 22(6): 668-671. [41] 孙居锋, 郭志雄, 潘惠英, 等. 叶酸拮抗剂类药物研究进展[J]. 化学通报, 2006, 69(2): 21. [42] Navarro-Perán E, Cabezas-Herrera J, Garcia-Canovas F, et al. The antifolate activity of tea catechins[J]. Cancer Research, 2005, 65(6): 2059-2064. [43] Alemdaroglu NC, Wolffram S, Boissel JP, et al. Inhibition of folic acid uptake by catechins and tea extracts in Caco-2 cells[J]. Planta Medica, 2007, 73(1): 27-32. [44] Lemos C, Peters GJ, Jansen G, et al. Modulation of folate uptake in cultured human colon adenocarcinoma Caco-2 cells by dietary compounds[J]. European Journal of Nutrition, 2007, 46(6): 329-336. [45] Navarro-Perán E, Cabezas-Herrera J, Sánchez-del-Campo L, et al. The anti-inflammatory and anti-cancer properties of epigallocatechin-3-gallate are mediated by folate cycle disruption, adenosine release and NF-κB suppression[J]. Inflammation Research, 2008, 57(10): 472-478. [46] Monteiro R, Calhau C, Martel F, et al. Modulation of MPP+ uptake by tea and some of its components in Caco-2 cells[J]. Naunyn-Schmiedeberg’s Arch Pharmacol, 2005, 372(2): 147-152. [47] Jodoin J, Demeule M, Béliveau R.Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols[J]. Biochimica et Biophysica Acta, 2002, 1542(1/2/3): 149-159. [48] Okamura S, Tamura H.Effect of herbal teas on conjugation reactions in a human colon carcinoma cell line, Caco-2[J]. Journal of Health Science, 2004, 50(2): 189-192. [49] Tamura H, Matsui M.Inhibitory effects of green tea and grape juice on the phenol sulfotransferase activity of mouse intestines and human colon carcinoma cell line, caco-2[J]. Biological & Pharmaceutical Bulletin, 2000, 23(6): 695-699. [50] Isozaki T, Tamura H.Epigallocatechin gallate (EGCG) inhibits the sulfation of 1-naphthol in a human colon carcinoma cell line, Caco-2[J]. Biological & Pharmaceutical Bulletin, 2001, 24(9): 1076-1078. [51] Chen ZP, Schell JB, Ho CT, et al. Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts[J]. Cancer Letters, 1998, 129(2): 173-179. [52] Lu J, Ho CT, Ghai G, et al. Differential effects of theaflavin monogallates on cell growth, apoptosis, and Cox-2 gene expression in cancerous versus normal cells[J]. Cancer Research, 2000, 60(22): 6465-6471. [53] Salucci M, Stivala LA, Maiani G, et al. Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2)[J]. British Journal of Cancer, 2002, 86(10): 1645-1651. [54] Subbaramaiah K, Altorki N, Chung WJ, et al. Inhibition of cyclooxygenase-2 gene expression by p53[J]. Journal of Biological Chemistry, 1999, 274(16): 10911-10915. [55] Intra J, Kuo SM.Physiological levels of tea catechins increase cellular lipid antioxidant activity of vitamin C and vitamin E in human intestinal Caco-2 cells[J]. Chemico-Biological Interactions, 2007, 169(2): 91-99. [56] Peng IW, Kuo SM.Flavonoid structure affects the inhibition of lipid peroxidation in Caco-2 intestinal cells at physiological concentrations[J]. The Journal of Nutrition, 2003, 133(7): 2184-2187. |