Effect of Green Tea on Diabetes

WANG Dong-feng; WANG Lin-ge; ZHANG Li; XU Ying; Bucheli Peter

doi:10.13305/j.cnki.jts.2010.04.002

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Journal of Tea Science ›› 2010, Vol. 30 ›› Issue (4) : 243-250. DOI: 10.13305/j.cnki.jts.2010.04.002

Effect of Green Tea on Diabetes

WANG Dong-feng¹, WANG Lin-ge¹, ZHANG Li¹, XU Ying¹, Bucheli Peter²

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Abstract

Diabetes mellitus is a disorder of metabolism and associated with long-term complications that affect eyes, heart, blood vessel, and kidney function. Though oral hypoglycemic agents and insulin are the main prevention and therapy treatment of diabetes, but they have severe side effects and fail to significantly alter the course of diabetic complications. As one of the most popular beverages consumed worldwide, green tea is being widely studied for its health benefits in recent years. In vitro and in vivo studies provide strong evidence that green tea presents a great prophylactic and therapeutic effect against diabetes. This review summarizes the beneficial effects of green tea on diabetes prevention and treatment.

Key words

diabetes mellitus / green tea / prevention / review / tea polyphenols / tea polysaccharides / therapy

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WANG Dong-feng, WANG Lin-ge, ZHANG Li, XU Ying, Bucheli Peter. Effect of Green Tea on Diabetes[J]. Journal of Tea Science. 2010, 30(4): 243-250 https://doi.org/10.13305/j.cnki.jts.2010.04.002

References

[1] Lefèbvre P.Diabetes yesterday, today and tomorrow. The action of the International Diabetes Federation[J]. Rev Med Liege, 2005, 60(5-6): 273-277.
[2] Iso H, Date C, Wakai K, et al. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults[J]. Ann Intern Med, 2006, 144(8): 554-562.
[3] Tsuneki H, Ishizuka M, Terasawa M, et al. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans[D]. BMC Pharmacol, 2004(4): 18.
[4] 全吉淑, 尹学哲, 柳明洙, 等. 绿茶提取物对小肠黏膜α-葡萄糖苷酶和葡萄糖转运能力的影响[J]. 中草药, 2005, 36(3): 411-412.
[5] Juskiewicz J, Zdunczyk Z, Jurgonski A, et al. Extract of green tea leaves partially attenuates streptozotocin-induced changes in antioxidant status and gastrointestinal functioning in rats[J]. Nutr Res, 2008, 28(5): 343-349.
[6] Wu LY, Juan CC, Hwang LS, et al. Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model[J]. Eur J Nutr, 2004, 43(2): 116-124.
[7] Chakravarthy BK, Gupta S, Gambhir SS, et al. Pancreatic beta-cell regeneration in rats by (-)-epicatechin[J]. Lancet, 1981, 21(8249): 759-760.
[8] Babu PVA, Sabitha KE, Shyamaladevi CS.Effect of green tea extract on advanced glycation and cross-linking of tail tendon collagen in streptozotocin induced diabetic rats[J]. Food Chem Toxicol, 2008, 46(1): 280-285.
[9] Mackness MI, Arrol S, Abbott C, et al. Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase[J]. Atherosclerosis, 1993, 104(1-2): 129-135.
[10] Aviram M, Rosenblat M, Bisgaier CL, et al. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its function: A possible peroxidative role for paraoxonase[J]. J Clin Invest, 1998, 101(8): 1581-1590.
[11] Steinberg D.Low density lipoprotein oxidation and its pathobiological significance[J]. J Biol Chem, 1997, 272(34): 20963-20966.
[12] Griendling KK, Alexander RW.Oxidative stress and cardiovascular diseases[J]. Circulation, 1997, 96(10): 3264-3265.
[13] Tas S, Sarandol E, Ziyanok S, et al. Effect of green tea on serum paraoxonase/arylesterase activities in streptozotocin-induced diabetic rats[J]. Nutr Res, 2005(25): 1061-1074.
[14] Babu PVA, Sabitha KE, Shyamaladevi CS.Green tea impedes dyslipidemia, lipid peroxidation, protein glycation and ameliorates Ca²+-ATPase and Na+/K+-ATPase activity in the heart of streptozotocin-diabetic rats[J]. Chemico-Biological Interactions, 2006, 162(2): 157-164.
[15] Wang DF, Zhou XL, Li L, et al. A rapid quantitative method for polysaccharides in green tea and oolong tea[J]. Eur Food Res Technol, 2008, 226(4): 691-696.
[16] 汪东风, 谢晓凤, 王世林, 等. 茶多糖的组分及理化性质[J]. 茶叶科学, 1996, 16(1): 1-8.
[17] Nie SP, Xie MY, Fu ZH, et al. Study on the purification and chemical compositions of tea glycoprotein[J]. Carbohydr Polymers, 2008, 71(4): 626-633.
[18] Wang DF, Wang CH, Li J, et al. Components and Activity of Polysaccharides from Coarse Tea[J]. J Agric Food Chem, 2001, 49(1): 507-510.
[19] lsigaki K, Takakuwa T, Takeo T, et al. Anti-diabetes mellitus effect of water-soluble tea polysaccharide[C]// Tea Science Society of Japan. Proceedings of International Symposium on Tea Science, 1992: 240-241.
[20] Zhou XL, Wang DF, Sun PN, et al. Effects of soluble tea polysaccharides on hyperglycemia in alloxan-diabetic mice[J]. J Agric Food Chem, 2007, 55(14): 5523-5528.
[21] 倪德江, 谢笔钧, 宋春和. 不同茶类多糖对实验型糖尿病小鼠治疗作用的比较研究[J]. 茶叶科学, 2002, 22(2): 160-163.
[22] 王莉英, 俞茂华, 陈蔚. 茶多糖对NOD小鼠1型糖尿病的预防作用[J]. 中华内分泌代谢杂志, 2006, 22(5): 476-479.
[23] 陈建国, 王茵, 梅松, 等. 茶多糖降血糖、改善糖尿病症状作用的研究[J]. 营养学报, 2003, 25(3): 253-255.
[24] Chen HX, Zhang M, Qu ZS, et al. Antioxidant activities of different fractions of polysaccharide conjugates from green tea (Camellia Sinensis)[J]. Food Chem, 2008, 106(2): 559-563.
[25] McCune LM, Johns T. Antioxidant activity in medicinal plants associated with the symptoms of diabetes mellitus used by the Indigenous Peoples of the North American boreal forest[J]. J Ethnopharmacol, 2002, 82(2-3): 197-205.
[26] Pisanti FA, Frascatore S, Papaccio G.Superoxide dismutase activity in the BB rat: a dynamic time-course study[J]. Life Sci, 1988, 43(20): 1625-1632.
[27] Salonen JT, Nyyssönen K, Tuomainen TP, et al. Increased risk of non-insulin dependent diabetes mellitus at low plasma vitamin E concentrations: a four year follow up study in men[J]. Br Med J, 1995, 311(7013): 1124-1127.
[28] Facchini FS, Humphreys MH, DoNascimento CA, et al. Relation between insulin resistance and plasma concentrations of lipid hydroperoxides, carotenoids, and tocopherols[J]. Am J Clin Nutr, 2000, 72(3): 776-779.
[29] Godin DV, Wohaieb SA, Garnett ME, et al. Antioxidant enzyme alterations in experimental and clinical diabetes[J]. Mol Cell Biochem, 1988, 84(2): 223-231.
[30] Collier A, Wilson R, Bradley H, et al. Free radical activity in type 2 diabetes[J]. Diabet Med, 1990, 7(1): 27-30.
[31] Baynes JW.Role of oxidative stress in development of complications in diabetes[J]. Diabetes, 1991, 40(4): 405-412.
[32] Chen HX, Zhang M, Xie BJ.Components and antioxidant activity of polysaccharide conjugate from green tea[J]. Food Chem, 2005, 90(1-2), 17-21.
[33] 李布青, 张慧玲, 舒庆龄, 等. 中低档绿茶中茶多糖的提取及降血糖作用[J]. 茶叶科学, 1996, 16(1): 67-72.
[34] 芮莉莉, 萧建中, 程义勇. 茶多糖对2型糖尿病小鼠降糖作用研究[J]. 中日友好医院学报, 2005, 19(2): 93-96.
[35] 全吉淑, 尹学哲, 及川和志. 茶多糖降糖作用机制[J]. 中国公共卫生, 2007, 23(3): 295-296.
[36] 刘超, 刘增义. 中药多糖降血糖研究进展[J]. 安徽中医学院学报, 1999, 18(5): 83-85.
[37] Sabu MC, Smitha K, Ramadasan K.Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes[J]. J Ethnopharmacol, 2002, 83(1-2): 109-116.
[38] 丁仁凤, 何普明, 揭国良. 茶多糖和茶多酚的降血糖作用研究[J]. 茶叶科学, 2005, 25(3): 219-224.
[39] Reiser KM.Nonenzymatic glycation of collagen in ageing and diabetes[J]. Proc Soc Biol Med, 1991, 196(1): 17-29.
[40] Aybar MJ, Sánchez Riera AN, Grau A, et al. Hypoglycemic effect of the water extract of Smallanthus sonchifolius(yacon) leaves in normal and diabetic rats[J]. J Ethnopharmacol, 2001(74): 125-132.
[41] Mathiesen ER, Rønn B, Storm B, et al. The natural course of microalbuminuria in insulin-dependent diabetes: a 10-year prospective study[J]. Diabet Med, 1995, 12(6): 482-487.
[42] 王蓓, 邓红, 苏宁, 等. 茶多酚对糖尿病大鼠活性氧表达的影响[J]. 东南大学学报(医学版), 2002, 21(1): 40-48.
[43] 王蓓, 李凯, 邓红, 等. 茶多酚对糖尿病肾病大鼠肾脏转化生长因子表达的影响[J]. 中日友好医院学报, 2003, 17(5): 286-289.
[44] 李清钊, 刘英莉, 姚林, 等. 茶多酚对糖尿病大鼠的保护作用[J]. 环境与职业医学, 2003, 20(3), 233-235.
[45] McKay DL, Blumberg JB. The role of tea in human health: An update[J]. J Am Coll Nutr, 2002, 1(1): 11-13.
[46] Rice-Evans CA, Miller NJ, Bolwell PG, et al. The relative antioxidant activities of plant-derived polyphenolic flavonoids[J]. Free Radic Res, 1995, 22(4): 375-383.
[47] Pillai SP, Mitscher LA, Menon SR, et al. Antimutagenic, antioxidant activity of green tea components and related compounds[J]. J Environ Pathol Toxicol Oncol, 1999, 18(3): 147-158.
[48] Salah N, Miller NJ, Paganga G, et al. Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants[J]. Arch Biochem Biophys, 1995, 322(2): 339-346.
[49] Hong JT, Ryu SR, Kim HJ, et al. Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury[J]. Brain Res Bull, 2000, 53(6): 743-749.
[50] Kashima M.Effects of catechins on superoxide and hydroxyl radical[J]. Chem Pharm Bull (Tokyo), 1999(47): 279-283.
[51] Atalay M, Laaksonen DE.Diabetes, oxidative stress and physical exercise[J]. J Sports Sci Med, 2002(1): 1-14.
[52] Memisogullari R, Taysi S, Bakan E.Antioxidant status and lipid peroxidation in Type II diabetes mellitus[J]. Cell Biochem Funct, 2003, 21(3): 291-296.
[53] Raskin P, Jovanovic L, Berger S, et al. Repaglinide/troglitazone combination therapy: improved glycemic control in Type 2 diabetes[J]. Diabetes Care, 2000, 23(7): 979-983.
[54] Cunningham J, Leffell M, Mearkle P, et al. Elevated plasma ceruloplasmin in insulin-dependent diabetes mellitus: evidence for increased oxidative stress as a variable complication[J]. Metabolism, 1995, 44(8): 996-999.
[55] Lipinski B.Pathophysiology of oxidative stress in diabetes mellitus[J]. J Diabet Complications, 2001, 15(4): 203-210.
[56] Sabu MC, Smitha K, Kuttan R.Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes[J]. J Ethnopharmacol, 2002, 83(1-2): 109-116.
[57] Leena P, Balaraman R.Effect of green tea extract on cisplatin induced oxidative damage on kidney and testes of rats[J]. Ars Pharm, 2005, 46(1): 15-18.
[58] HS Moon, HG Lee, YJ Choi, et al. Proposed mechanisms of(-)-epigallocatechin-3-gallate for anti-obesity[J]. Chem Biol Interact, 2007(167): 85-98.
[59] Kobayashi Y, Suzuki M, Satsu H, et al. Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism[J]. J Agric Food Chem, 2000, 48(11): 5618-5623.
[60] Matsumoto N, Ishigaki F, Ishigaki A, et al. Reduction of blood glucose level by tea catechin[J]. Biosci Biotechnol Biochem, 1993, 57(4): 525-527.
[61] Anderson RA, Polansky MM.Tea enhances insulin activity[J]. J Agric Food Chem, 2002, 50(24): 7182-7186.
[62] Waltner-Law ME, Wang XL, Law BK, et al. Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production[J]. J Biol Chem, 2002, 277(38): 34933-34940.
[63] Anton S, Melville L, Rena G.Epigallocatechin gallate (EGCG) mimics insulin action on the transcription factor FOXO1a and elicits cellular responses in the presence and absence of insulin[J]. Cellular Signalling, 2007, 19(2): 378-383.
[64] 蒋志嵩, 康远华. 茶色素对糖尿病肾病患者β2-微球体蛋白影响的自身对照试验[J]. 药物流行病学杂志, 2002, 9(4): 173-175.
[65] 夏成云, 周京国, 谢建平, 等. 茶色素对早期糖尿病肾病患者尿内皮素排泄的影响及其意义[J]. 中国医师杂志, 2002, 4(2): 156-158.
[66] 马大荣, 周巧云, 宋荣秀, 等. 茶色素抗高血脂、异常血液流变和微循环障碍的临床研究[J]. 中国血液流变学杂志, 2000, 10(4): 218-220.