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Journal of Tea Science ›› 2018, Vol. 38 ›› Issue (4): 430-438.doi: 10.13305/j.cnki.jts.2018.04.012

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Alleviative Effects of Aged Liupao Tea on Lipid Metabolism and Liver Injury in Hyperlipidemic Mice

WU Wenliang1,2,3,4, LIU Zhonghua1,2,3,*, LIN Yong1,2,3,*, HUANG Jian′an1,2,3, ZUO Gaolong1,2, TENG Cuiqin5, LONG Zhirong6, QIU Ruijin5, CAO Zhonghuan5   

  1. 1. Key Lab of Tea Science of Education Ministry, Hunan Agricultural University, Changsha 410128, China;
    2. National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Changsha 410128, China;
    3. Collaborative Innovation Center of Utilization of Functional Ingredients from Botanicals, Changsha 410128, China;
    4. Tea of Institute, Hunan Academy of Agricultural Sciences, Changsha 410125, China;
    5. Wuzhou Academy of Liupao Tea, Wuzhou 543003, China;
    6. Wuzhou of Office Tea Industry Development, Wuzhou 543003, China
  • Received:2017-12-12 Revised:2018-01-30 Online:2018-08-15 Published:2019-10-15

Abstract: To investigate the alleviative effects of aged Liupao tea on lipid metabolism and liver injury in hyperlipidemic mice, the changes of main chemical substances in Liupao tea of different storage ages were analyzed. The hyperlipidemia model mice were established by feeding a high fat and sugar diet, and Liupao tea groups were given daily oral administration of water extract of selected aged Liupao tea. The changes of related physiological and biochemical indexes and tissue morphology in mice were observed. The results showed that Liupao tea samples stored for 15 years were selected as the representative of the aged Liupao tea, which was used in subsequent experiments. Compared with the hyperlipidemia model group, aged Liupao tea especially medium or high dose groups could significantly decrease the contents of TC, TG, and LDL-C levels, increase the content of HDL-C, suppress the activities of ALT and AST in the serum, and moderate liver oxidative stress,. Pathological sections of liver and adipose tissue showed that aged Liupao tea could reduce the formation of lipid droplets in liver cells and inhibit the enlargement of fat cells in a dose dependent manner. In conclusion, aged Liupao tea of normal dose could effectively improve lipid metabolism disorder and liver injury in mice induced by high fat and sugar diet.

Key words: aged Liupao tea, hyperlipidemia, lipid metabolism, liver injury, alleviative effect

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