茶多酚改善胰岛素抵抗的初步研究

doi:10.13305/j.cnki.jts.2014.02.006

Abstract

Abstract: To study the effects of tea polyphenols (TP) on insulin resistance in the model rats of T2DM with NAFLD and its mechanism. Adult healthy SD rats were randomly divided into six equal groups: normal control (NC) group, model group, TP group, metformin group, fat liver (FL) group and FL+TP group. In the end of two weeks treatment, the levels of fasting serum glucose, insulin, TG and the TG of liver were measured. Two weeks after treatment, the fasting blood glucose and insulin and insulin sensitivity index of the TP group and metformin group were both significantly lower than those of the model group (both P<0.05). The TP group and FL+TP group compared with model group and FL group, the TP significantly reduce the levels of TG of the liver (both P<0.05). TP can efficiently ameliorated lipid metabolism in the liver tissue of rats and improve insulin sensitivity in the rat model of type 2 diabetes mellitus with fatty liver.

Key words: tea polyphenols, insulin resistance, triglyceride, T2DM

CLC Number:

XIA Jiajie, XUE Meng, JIN Meng, WU Jueli, LIU Handeng. Preliminary Reserch of Tea Polyphenols on Insulin Resistance[J]. Journal of Tea Science, 2014, 34(2): 144-148.

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Preliminary Reserch of Tea Polyphenols on Insulin Resistance

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