茶叶的神经保护作用研究进展

doi:10.13305/j.cnki.jts.2011.02.001

Abstract

Abstract: Tea is a natural healthy beverage and recent medicinal researches have been proven that teas have the neuroprotection function. In the neuroprotective effects of tea, catechins, L-theanine and caffeine work together to modulate the nervous system especially central nervous system in a multi-targets way through multiple pathways. Tea showed the free radical Scavenging function via the antioxidative roles. Besides, it showed the function of modulation the neurotransmitters as glutamic acid, γ-aminobutyric acid and acetylcholine etc. and their related receptors, prevention of tau protein phosphorylation and intracellular calcium overloads, regulation of protein kinase C signal transduction pathway, modulation of inflammatory factors, elevation of the neurotrophic factors’ level, elimination of vascular risk factors and attenuation of neuron apoptosis. Recent progress on the neuroprotective effects of tea was reviewed in this paper.

Key words: tea, active component, antioxidation, neuroprotection

CLC Number:

TS272
R742

LI Da-xiang, XIAN Shu, YANG Wei, WAN Xiao-chun. Progress on the Neuroprotective Effects of Tea[J]. Journal of Tea Science, 2011, 31(2): 79-86.

References

[1] 赵保路. 自由基、天然抗氧化剂与神经退行性疾病[J]. 生物物理学报, 2010, 26(4): 263-274.
[2] 刘东华,毕明刚.中药提取成分抗阿尔茨海默病研究进展[J].国际药学研究杂志,2009,36(5):340-344.
[3] 宛晓春. 茶叶生物化学: 第三版[M]. 北京: 中国农业出版社, 2003: 9, 30, 34, 39.
[4] 朱永兴, Huang H.茶与健康[M]. 北京: 中国农业科学技术出版社, 2004: 5.
[5] Zhao B L.The health effects of tea polyphenols and their antioxidant mechanism[J]. J Clin Biochem Nutr, 2006, 38: 59-68.
[6] 高欣, 唐希灿. 神经退行性疾病的早期信号: 线粒体功能障碍[J]. 生命科学, 2006, 18(2): 138-144.
[7] 王海燕, 张新卿. 茶的神经保护作用[J]. 中华老年医学杂志, 2006, 25(12): 942-945.
[8] Assuncăo M, Santos-Marques M J, Carvalho F, et al. Chronic green tea consumption prevents age-related changes in rat hippocampal formation[J]. Neurobiol. Aging. doi:10.1016/j.neurobiolaging.2009.03.016.
[9] Xu Y, Zhang J J, Xiong L, et al. Green tea polyphenols inhibit cognitive impairment induced by chronic cerebral hypoperfusion via modulating oxidative stress[J]. J Nutr Biochem, 2010, 21(8): 741-748.
[10] Wei IH, Wu YC, Wen CY, et al. Green tea polyphenol (-)-epigallocatechin gallate attenuates the neuronal NADPH-d/nNOS expression in the nodose ganglion of acute hypoxic rats[J]. Brain Res, 2004, 999(1): 73-80.
[11] Kim JS, Kim JM, O JJ, et al. Inhibition of inducible nitric oxide synthase expression and cell death by (-)-epigallocatechin-3-gallate, a green tea catechin, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease[J]. J Clin Neurosci, 2010, 17(98): 1165-1168.
[12] 赵保路. 茶多酚保护脑神经防止帕金森病损伤作用及其分子机理[J]. 生物化学与生物物理进展, 2008, 35(7): 735-743.
[13] 颜菡, 唐希灿. β-淀粉样蛋白的代谢与调控: 阿尔采末病的潜在治疗靶点[J]. 生命科学, 2007, 19(4): 409-416.
[14] Jeon SY, Bae K, Seong YH, et al. Green tea catechins as a BACE1 (beta-secretase) inhibitor[J]. Bioorg Med Chem Lett, 2003, 13(22): 3905-3908.
[15] Rezai-zadeh K, Shytle D, Sun N, et al.Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice[J]. J Neurosci, 2005, 25(38): 8807-8814.
[16] Mandel SA, Amit T, Weinreb O, et al. Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases[J]. CNS Neurosci Therap, 2008, 14(4): 352-365.
[17] Levites Y,Amit T,Mandel S, et al. Neuroprotection and neurorescue against Aβ toxicity and PKC-dependent release of non-amyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate[J]. FASEB J, 2003, 17(8): 952-954.
[18] 田建英, 杨浩. nAChR 介导茶多酚EGCG的神经保护作用[J]. 中国药理学通报, 2007, 23(11): 1494-1496.
[19] Bastianetto S, Yao ZX, Papadopoulos V, et al. Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity[J]. Eur J Neurosci, 2006, 23(1): 55-64.
[20] Haque AM, Hashimoto M, Katakura M, et al. Green tea catechins prevent cognitive deficits caused by Aβ_1-40 in rats[J]. J Nutr Biochem, 2008, 19(9): 619-626.
[21] Kim CY, Lee C, Park GH, et al. Neuroprotective effect of epigallocatechin-3-gallate against β-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity[J]. Arch Pharmacal Res, 2009, 32(6): 869-881.
[22] 徐铮奎. 天然镇静剂——茶氨酸产品开发现状与前景瞻望[J]. 中国制药信息, 2007, 23(3): 34-37.
[23] Yamada T, Okubo T, Juneja LR, et al. Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission[J]. Nutr Neurosci, 2005, 8(4): 219-226.
[24] Nathan PJ, Lu K, Gray M, et al. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent[J]. J Herb Pharmacother, 2006, 6(2): 21-30.
[25] Rosso A, Mossey J, Lippa C.F. Caffeine: neuroprotective functions in cognition and Alzheimer’s disease[J]. Am J Alzheimer’s Dis Other Demen, 2008, 23(5): 417-422.
[26] Lin SM, Wang SW, Ho SC, et al. Protective effect of green tea(-)-epigallocatechin-3-gallate against the monoamine oxidase B enzyme activity increase in adult rat brains[J]. Nutrition, doi:10.1016/j.nut.2009.11.022
[27] Bernareggi A, Dueńas Z, Reyes-Ruiz JM, et al. Properties of glutamate receptors of Alzheimer’s disease brain transplanted to frog oocytes[J]. Proc Natl Acad Sci, USA, 2007, 104(8): 2956-2960.
[28] 严钰, 丁启龙. 中药单体及有效部位的神经保护作用机制研究进展[J]. 药学进展, 2007, 31(4): 154-159.
[29] Di X, Yan j, Zhao Y, et al. L-theanine protects the app (swedish mutation) Transgenic sh-sy5y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway[J]. Neuroscience, 2010, 168(3): 778-786.
[30] Yu JX, Jia YQ, Guo YS, et al. Epigallocatechin-3-gallate protects motor neurons and regulates glutamate level[J]. FEBS Lett, 2010, 584(13): 2921-2925.
[31] Jang S, Jeong HS, Park JS, et al. Neuroprotective effects of (-)-epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI₃K pathway and NO inhibition[J]. Brain Res, 2010, 1313: 25-33.
[32] Adachi N, Tomonaga S, Tachibana T, et al. (-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain[J]. Eur J Pharmacol, 2006, 531/213: 171-175.
[33] Vignes M, Maurice T, Lanté F, et al. Anxiolytic properties of green tea polyphenols (-)-epigallocatechin gallate (EGCG)[J]. Brain Res, 2006, 1110(1): 102-115.
[34] 王潭, 席娜娜, 郑荣远. 咖啡碱作为中枢腺苷受体拮抗剂的应用[J]. 国际药学研究杂志, 2009, 36(4): 249-253.
[35] Piccardi M, Congiu D, Squassina A, et al. Alzheimer′s disease: case2control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample[J]. Am J Med Genet B N europsychiatr Genet, 2007, 144(7): 895-899.
[36] Okello EJ, Savelev SU, Perry E.K. In vitro anti-beta-secretase and dual anti-cholinesterase activities of Camellia sinensis L.(tea) relevant to treatment of dementia[J]. Phytother Res, 2004, 18(8): 624-627.
[37] Li R, Peng N, Du F, et al. Epigallocatechin gallate protects dopaminergic neurons against 1-methyl-4-pheny1-1,2,3,6-tetrahydropyridine-induced neurotoxicity by inhibiting microglial cell activation[J]. J South Med Univ(南方医科大学学报), 2006, 26(4): 376-380.
[38] Levites Y, Amit T, Youdim MB, et al. Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action[J]. J Biol. Chem, 2002, 277(34): 30574-30580.
[39] Kalfon L, Youdim M B, Mandel S.A. Green tea polyphenol (-)-epigallocatechin-3-gallate promotes the rapid protein kinase C- and proteasome-mediated degradation of Bad: implications for neuroprotection[J]. J Neurochem, 2007, 100(4): 992-1002.
[40] Li Q, Zhao HF, Zhang ZF, et al. Long-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic AMP-response element binding protein signaling cascade[J]. Neurosci, 2009, 159(4): 1208-1215
[41] Li Q, Zhao HF, Zhang ZF, et al. Long-term administration of green tea catechins prevents spatial learning and memory impairment in SAMP8 mice by decreasing Aβ_1-42 oligomers and up-regulating synaptic plasticity related proteins in hippocampus[J]. Neurosci, 2009, 163(3): 741-749.
[42] Connolly S, Kingsbury TJ.Caffeine modulates CREB-dependent gene expression in developing cortical neurons[J]. Biochem Biophys Res Commun, 2010, 397(2): 152-156.
[43] 盛之玲, 曲梅花, 何海进, 等. HeLa、HEK293、SH-SY5Y细胞中的Tau 蛋白[J]. 生物化学与生物物理进展, 2008, 35(12): 1364-1370.
[44] Rezai-Zadeh K, Arendash GW, Hou H, et al. Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice[J]. Brain Res, 2008, 1214: 177-187.
[45] 方芳, 崔志清, 韩永晶. 茶儿茶素抗大鼠脑缺血再灌注损伤与对脑细胞内Ca²+的作用[J]. 中国药学杂志, 2003, 38(12): 917-919.
[46] 冯亮, 徐辰, 郑浩, 等. 茶多酚对D2半乳糖诱导糖基化大鼠脑损害的干预作用[J]. 中国老年学杂志, 2008, 28(13): 1251-1254.
[47] Akiyama H, Barg er S, Barnum S, et al. Inflammation and Alzheimer’s disease[J]. Neuro Biol Aging, 2000, 21(3): 383-421.
[48] Brothers HM, Marchalant Y, Wenk GL.Caffeine attenuates lipopolysaccharide-induced neuroinflammation[J]. Neurosci Lett, 2010, 480(2): 97-100.
[49] 陈国钱, 郑荣远, 王新施, 等. 咖啡碱对实验性自身免疫性脑脊髓炎大鼠的IFN-γ和TGF-β的影响[J]. 温州医学院学报, 2008, 38(6): 491-493.
[50] Aktas O, Prozorovski T, Smorodchenko A, et al. Green tea epigallocatechin-3-gallate mediates T cellular NF-κB inhibition and exerts neuroprotection in Autoimmune Encephalomyelitis[J]. J Immunol, 2004, 173(9): 5794-5800.
[51] Lee SY, Lee JW, Yoo HS, et al. Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms[J]. Mol Brain Res, 2005, 140(1/2): 45-54.
[52] 蔡飞, 李彩蓉, 吴基良, 等. 茶黄素对大鼠脑缺血再灌注损伤后细胞凋亡及凋亡相关基因的影响[J]. 时珍国医国药, 2008, 19(6): 1396-1398.
[53] 苏兴文, 皮荣标, 林穗珍, 等. 咖啡碱对谷氨酸诱导神经元凋亡的保护作用[J]. 中国药理学通报, 1999, 15(6): 509-512.
[54] 王海燕, 张新卿. 茶对血管性认知功能损害的保护作用[J]. 中华预防医学杂志, 2007, 41(3): 222-224.
[55] Sharangi AB.Medicinal and therapeutic potentialities of Tea (Camellia sinensis L.) - A review[J]. Food Res Int, 2009, 42(5/6): 529-535.
[56] Lee H, Bae HB, Lee SR.Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils[J]. J Neurosci Res, 2004, 77(6): 892-900.
[57] Arab L, Liu WQ, Elashoff D.Green and black tea consumption and risk of stroke: a Meta-analysis[J]. Stroke, 2009, 40(5): 1786-1792.
[58] Arab L, Liebeskind DS.Tea, flavonoids and stroke in man and mouse[J]. Arch Biochem. Biophys, 2010, 501(1): 31-36.
[59] Thielecke F, Boschmann M.The potential role of green tea catechins in the prevention of the metabolic syndrome - A review[J]. Phytochemistry, 2009, 70(1): 11-24.
[60] 石亚亚, 贾尚智, 闵彩云. 茶氨酸保健功能研究进展[J]. 氨基酸和生物资源, 2010, 32(1): 52-56.
[61] Haskell CF, Kennedy DO, Milne AL, et al. The effects of L-theanine, caffeine and their combination on cognition and mood[J]. Biol Psychol, 2008, 77(2): 113-122.
[62] Einöther SJL, Martens VEG, Rycroft JA, et al. L-Theanine and caffeine improve task switching but not intersensory attention or subjective alertness[J]. Appetite, 2010, 54(2): 406-409.
[63] Park KW, Oh JH, Yoo HS, et al. (-)-Epigallocatechin-3-O-gallate (EGCG) reverses caffeine-induced anxiogenic-like effects[J]. Neurosci. Lett., 2010, 481(2): 131-134.
[64] 马强. 体力运动益于脑健康的神经生物学基础[J]. 解放军预防医学杂志, 2008, 26(4): 305-308.
[65] Murase T, Haramizu S, Ota N, et al. Tea catechin ingestion combined with habitual exercise suppresses the aging-associated decline in physical performance in senescence-accelerated mice[J].Am J Physiol, 2008, 295(1): R281-R289.
[66] Huo C, Wan SB, Lam WH, et al. The challenge of developing green tea polyphenols as therapeutic agents[J]. Immunopharm, 2008, 16(5): 248-252.

Progress on the Neuroprotective Effects of Tea

PDF (PC)

Knowledge

Cited

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Comments

Recommended 0

[1]	TANG Haikun, ZHANG Lanjun, ZHANG Panpan, LIU Benying. Research Progress on Chemical Constituents and Biological Activities of Alkaloids in Tea [J]. Journal of Tea Science, 2025, 45(5): 727-741.
[2]	TU Yiyi, ZHANG You, XU Ting, CHEN Junjie, WANG Yuchun, LÜ Wuyun. Loop-mediated Isothermal Amplification-based Detection of Colletotrichum camelliae [J]. Journal of Tea Science, 2025, 45(5): 770-782.
[3]	JIANG Li, LI Duojiao, HU Xinrong, SHEN Yingzi, ZHENG Zhaisheng, WENG Xiaoxing, LIU Shujing, BIAN Xiaodong, YUAN Ming'an, CHEN Xuan. Effects of Different Cultivation Patterns on Physiological and Biochemcial Characteristics of New Shoots in Seed-Leaf Dual-Purpose Tea Plants [J]. Journal of Tea Science, 2025, 45(5): 783-794.
[4]	WANG Kairong, ZHANG Longjie, LIANG Yuerong, LI Xiaoxiang, ZHENG Xinqiang. Identification and Classification of Tea Leaf Color and Establishment of A Tea Leaf Color System [J]. Journal of Tea Science, 2025, 45(5): 795-807.
[5]	LI Jing, HU Xinlong, TANG Huishan, GUO Jinling, HU Guangcan, FENG Depin, QIU Fangfang, WANG Mingle. Integrated Sensory Evaluation and Metabolomics Analysis of the Quality Characteristics of Yihong Black Tea with Different Levels of Tenderness [J]. Journal of Tea Science, 2025, 45(5): 808-820.
[6]	GUO Yu, XIAO Liuyu, DU Qiuyi, TIAN Ye, HAN Yu. Study on Comprehensive Optimization of the Extraction Process and Emulsion Loading System of Water-extracted Polysaccharides from Qingzhuan Tea and Alkali-extracted Polysaccharides from Tea Residue [J]. Journal of Tea Science, 2025, 45(5): 821-840.
[7]	SU Lin, HUANG Zihao, SUN Dan, CHEN Jinhua, ZHENG Yajie, LU Ying. Study on the Hypoglycemic Effects of Major Compounds in White Tea Based on Network Pharmacology and Zebrafish Model [J]. Journal of Tea Science, 2025, 45(5): 841-851.
[8]	WANG Yonghui, WANG Duofeng, LI Xuemin, SHI Tianbin, WU Lidong, LIU Zaiguo, ZHANG Guangzhong, ZHAO Fengyun. Study on the Physicochemical Components and in Vitro Antioxidant Differences of Green Tea from Longnan, Gansu and Jinhua, Zhejiang [J]. Journal of Tea Science, 2025, 45(5): 852-864.
[9]	CHEN Junrui, HU Junming, SHI Yuanzhi, WEI Xianghua, SONG Chuankui, ZHANG Junhui, ZHENG Fuhai, SUO Guangli. The Effects of Biochar-based Fertilizer on the Physical Stability of Organic Carbon in Soil Aggregates of Tea Gardens [J]. Journal of Tea Science, 2025, 45(5): 865-878.
[10]	LI Bing, ZHU Yong, XIA Chenglong, LI Feilong, CAI Zhenyang, WU Hao. Lightweight Online Sorting Method of Milled Tea Based on Improved YOLOv5s [J]. Journal of Tea Science, 2025, 45(5): 879-897.
[11]	MENG Chao, LIANG Tao, ZHANG Xia, WANG Wanhong, DONG Huanglin, LI Ming. Research on Tea Light Complementary Mode Based on Tea Planting and Photovoltaic Power Generation [J]. Journal of Tea Science, 2025, 45(5): 898-908.
[12]	ZHOU Yide, CHEN Jialin, WU Junmei, ZHAO Hongbo, SUN Binmei, LIU Shaoqun, ZHENG Peng. Nitrogen Metabolism Genes in Tea Plant: Research Progress on the Environmental Stress Adaptation Mechanism and Breeding Application [J]. Journal of Tea Science, 2025, 45(4): 545-558.
[13]	SUN Mengzhen, HU Zhihang, YANG Kaixin, ZHANG Jiaqi, ZHANG Nan, XIONG Aisheng, LIU Hui, ZHUANG Jing. Identification of Circadian Clock CsLUX Gene and Its Effects on Photosynthetic Characteristics in Tea Plants [J]. Journal of Tea Science, 2025, 45(4): 559-570.
[14]	MENG Zhaona, Fida Hussain Magsi, ZHAO Dongxiang, ZHOU You, LI Jianlong, NONG Hongqiu, LONG Yaqin, ZHAO Yuanyan, HUANG Liyun, BIAN Lei, LI Zhaoqun, LUO Zongxiu, XIU Chunli, FU Nanxia, CHEN Zongmao, CAI Xiaoming. Investigation on the Helopeltis (Hemiptera) Species in Tea Gardens of China [J]. Journal of Tea Science, 2025, 45(4): 615-624.
[15]	SUN Yu, ZHOU Li, ZHANG Xinfu, SUN Hezhi. Determination of 20 Phthalate Acid Esters in Tea Leaves by GC-MS/MS [J]. Journal of Tea Science, 2025, 45(4): 625-636.