茶叶对血小板活化的影响研究进展

doi:10.13305/j.cnki.jts.2015.05.008

Abstract

Abstract: Platelet activation is the basis of the incidence of many cardiovascular disease, antiplatelet drugs could block the cascade of platelet aggregation in different levels. As confirmed by clinical research and animal experiments, tea and tea ingredients can inhibit platelet aggregation. Catechins exhibit a structure-activity relationship in antiplatelet effect. This review summarized recent progress in the effect of tea and tea ingredients on platelet activity or platelet aggregation in vitro, in vivo and ex vivo, and also the effect on thrombus and coagulation system. The mechanism of anti-aggregatory effect of tea is explored, which provide further confirmation for its antithrombotic function and the preventive effect for cardiovascular disease.

Key words: tea ingredients, platelet activation, platelet aggregation, antithrombotic

CLC Number:

TS272
Q461

CHEN Ping, QIU Pei, CHENG Hao, ZHOU Ying, GONG Shuying. Review on the Effect of Tea on Platelet Activation[J]. Journal of Tea Science, 2015, 35(5): 458-464.

References 25

[1]	侯明, 戴克胜, 彭军. 血小板疾病[M]. 北京: 科学技术文献出版社, 2013: 48-61.
[2]	Sharis PJ, Cannon CP, Loscalzo J.The antiplatelet effects of ticlopidine and clopidogrel[J]. Annals of Internal Medicine, 1998, 129(5): 394-405.
[3]	胡翊群, 赵涵芳. 血液系统[M]. 上海: 上海交通大学出版社, 2012: 105-116.
[4]	Matsumura K, Takayama H, Bae JY, et al. Preservation of platelets by adding epigallocatechin-3-o-gallate to platelet concentrates[J]. Cell Transplant, 2009, 18(5): 521-528.
[5]	Carnevale R, Loffredo L, Nocella C, et al. Epicatechin and catechin modulate endothelial activation induced by platelets of patients with peripheral artery disease[J]. Oxid Med Cell Longev, 2014, ID691015.
[6]	Lill G, Voit S, Schrör K, et al. Complex effects of different green tea catechins on human platelets[J]. FEBS Letter, 2003, 546(2/3): 265-270.
[7]	Jin YR, Im JH, Park ES, et al. Antiplatelet activity of epigallocatechingallate is mediated by the inhibition of PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium-ATPase activity[J]. J Cardiovasc Pharmacol, 2008, 51(1): 45-54.
[8]	Ok WJ, Cho HJ, Kim HH, et al. Epigallocatechin-3-gallate has an anti-platelet effect in a cyclic AMP-dependent manner[J]. J Atheroscler Thromb, 2012, 19(4): 337-348.
[9]	Son DJ, Cho MR, Jin YR, et al. Antiplatelet effect of green tea catechins: a possible mechanism through arachidonic acid pathway[J]. Prostaglandins Leukot Essent Fatty Acids, 2004, 71(1): 25-31.
[10]	庞爱明, 阮长耿. 绿茶的主要成分表没食子儿茶素没食(EGCG)对血小板功能影响的研究[J]. 中国血液流变学杂志, 2004, 14(1): 37-39.
[11]	Kang WS, Lim IH, Yuk DY, et al. Antithrombotic activities of green tea catechins and (-)-epigallocatechingallate[J]. Thromb Res, 1999, 96(3): 229-237.
[12]	Sugatani J, Fukazawa N, Ujihara K, et al. Tea polyphenols inhibit acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and platelet-activating factor-induced platelet aggregation[J]. Int Arch Allergy Immunol, 2004, 134(1): 17-28.
[13]	Steptoe A, Gibson EL, Vuononvirta R, et al. The effects of chronic tea intake on platelet activation and inflammation: a double-blind placebo controlled trial[J]. Atherosclerosis, 2007, 193(2): 277-282.
[14]	Hodgson JM, Puddey IB, Burke V, et al. Acute effects of ingestion of black tea on postprandial platelet aggregation in human subjects[J]. Br J Nutr, 2002, 87(2): 141-145.
[15]	Hodgson JM, Puddey IB, Mori TA, et al. Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans[J]. Eur J Clin Nutr, 2001, 55(10): 881-886.
[16]	Wolfram RM, Oguogho A, Efthimiou Y, et al. Effect of black tea on (iso-)prostaglandins and platelet aggregation in healthy volunteers[J]. Prostaglandins Leukot Essent Fatty Acids, 2002, 66(5/6): 529-533.
[17]	Chen XQ, Wang XB, Guan RF, et al. Blood anticoagulation and antiplatelet activity of green tea (-)-epigallocatechin (EGC) in mice[J]. Food Funct, 2013, 4(10): 1521-1525.
[18]	Ryou SH, Kang MS, Kim KI, et al. Effects of green tea or Sasaquelpaertensis bamboo leaves on plasma and liver lipids, erythrocyte Na efflux, and platelet aggregation in ovariectomized rats[J]. Nutr Res Pract, 2012, 6(2): 106-112.
[19]	Choi JH, Chang HW, Rhee SJ.Effect of green tea catechin on arachidonic acid cascade in chronic cadmium-poisoned rats[J]. Asia Pac J Clin Nutr, 2002, 11(4): 292-297.
[20]	王贤波, 成浩, 赵芸, 等. 茶叶中EGCG对小鼠抗凝血作用实验研究[J]. 茶叶科学, 2011, 31(6): 532-536.
[21]	余丽萍. 茶色素体内外抗血小板聚集作用的观察[J]. 临床荟萃, 2000, 15(7): 320.
[22]	Lee DH, Kim YJ, Kim HH, et al. Inhibitory effects of epigallocatechin-3-gallate on microsomal cyclooxygenase-1 activity in platelets[J]. Biomol Ther (Seoul), 2013, 21(1): 54-59.
[23]	Deana R, Turetta L, Donella-Deana A, et al. Green tea epigallocatechin-3-gallate inhibits platelet signalling pathways triggered by both proteolytic and non-proteolyticagonistsn[J]. Thromb Haemost, 2003, 89(5): 866-874.
[24]	房磊, 王捷熙, 刘海霞, 等. 负载表没食子儿茶素没食子酸酯对血小板功能与凋亡等影响[J]. 中国实验血液学杂志, 2011(3): 218-222.
[25]	Widlansky ME, Duffy SJ, Hamburg NM, et al. Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease[J]. Free RadicBiol Med, 2005, 38(4): 499-506.

Review on the Effect of Tea on Platelet Activation

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 25

Related Articles 15

Metrics

Comments

Recommended 0

[1]	WANG Yonghui, WANG Duofeng, LI Xuemin, SHI Tianbin, WU Lidong, LIU Zaiguo, ZHANG Guangzhong, ZHAO Fengyun. Study on the Physicochemical Components and in Vitro Antioxidant Differences of Green Tea from Longnan, Gansu and Jinhua, Zhejiang [J]. Journal of Tea Science, 2025, 45(5): 852-864.
[2]	LI Bing, ZHU Yong, XIA Chenglong, LI Feilong, CAI Zhenyang, WU Hao. Lightweight Online Sorting Method of Milled Tea Based on Improved YOLOv5s [J]. Journal of Tea Science, 2025, 45(5): 879-897.
[3]	MENG Chao, LIANG Tao, ZHANG Xia, WANG Wanhong, DONG Huanglin, LI Ming. Research on Tea Light Complementary Mode Based on Tea Planting and Photovoltaic Power Generation [J]. Journal of Tea Science, 2025, 45(5): 898-908.
[4]	ZHOU Yide, CHEN Jialin, WU Junmei, ZHAO Hongbo, SUN Binmei, LIU Shaoqun, ZHENG Peng. Nitrogen Metabolism Genes in Tea Plant: Research Progress on the Environmental Stress Adaptation Mechanism and Breeding Application [J]. Journal of Tea Science, 2025, 45(4): 545-558.
[5]	SUN Mengzhen, HU Zhihang, YANG Kaixin, ZHANG Jiaqi, ZHANG Nan, XIONG Aisheng, LIU Hui, ZHUANG Jing. Identification of Circadian Clock CsLUX Gene and Its Effects on Photosynthetic Characteristics in Tea Plants [J]. Journal of Tea Science, 2025, 45(4): 559-570.
[6]	HOU Aixiang, YANG Xiaolu, WU Wenliang, XIAO Yu, LI Shi, HUANG Yiwen, JU Rongfang. Analysis of Volatile Flavor Compounds and Microbial Diversity in Anhua Black Tea Processed by Different Fermentation Techniques [J]. Journal of Tea Science, 2025, 45(4): 637-654.
[7]	JIA Jiangming, WANG Xiang, ZHOU Yujie, WU Chuanyu, CHEN Jianneng, YU Rong, LI Yujie. Collaborative Picking Planning for A Dual-Arm Tea-Picking Robot [J]. Journal of Tea Science, 2025, 45(4): 671-686.
[8]	ZHANG Mengxue, JIANG Heyuan, WANG Weiwei, YE Shuixin. Differences in Digestive Stability of Catechins in Dry Tea and Instant Tea Powder [J]. Journal of Tea Science, 2025, 45(4): 699-711.
[9]	ZHANG Kaili, LI Xiang. Advances on Sensory Characteristics and Physiological Activity of Qingzhuan Brick Tea [J]. Journal of Tea Science, 2025, 45(3): 361-378.
[10]	GE Chenxi, TANG Desong, ZHANG Lin, FU Shangwen, ZHANG Yingbin, LIANG Huiling. Evaluation of Aroma Enhancement Effect of Jasmine Hydrosol on Jasmine Tea and Its Influencing Factors [J]. Journal of Tea Science, 2025, 45(3): 465-484.
[11]	CHEN Yuan, AN Huimin, HUANG Yiwen, JIANG Youcang, YING Jiaqi, WANG Sirui, LI Shi, LIU Zhonghua, HUANG Jian'an. Unveiling the Characteristic Taste Quality Compounds of Jasmine Tea Based on Electronic Tongue and Metabolomics Techniques [J]. Journal of Tea Science, 2025, 45(3): 485-496.
[12]	SHEN Shuai, REN Ning, ZHENG Hang, YU Guohong, CHEN Zhidong. Design and Testing of Tea Garden Crawler Plowing Machine [J]. Journal of Tea Science, 2025, 45(2): 273-283.
[13]	JIA Zhijun, JIANG Jiayin, XU Jiajun, LI Yang, DONG Chunwang, SONG Wentao, LI Kai, WEI Chizhang, YAO Yuchen, YAO Lijian, YANG Zidong, LIU Haoyang, MA Rong. Optimization and Testing of Tea Garden Biomimetic Tillage Machine Based on DEM-MBD Coupling Algorithm [J]. Journal of Tea Science, 2025, 45(2): 284-302.
[14]	CHENG Haiyan, TU Linyue, CHEN Lin, XU An'an, XIE Hengtong, XU Ping. Spatiotemporal Changes of Amino Acids and Polyphenols in Leaves and Stems during Tea Withering [J]. Journal of Tea Science, 2025, 45(2): 303-317.
[15]	ZHANG Peng, HUANG Yan, WEI Chengjiang, ZHENG Zhiqiang, WU Weiwei, ZHENG Changkun, SHEN Weiwei, YU Yingjie, LIN Fuming, SUN Weijiang. The Study of Volatile Components in Three Scented Types of Black Tea Based on HS-SPME-GC-MS and Molecular Docking Technology [J]. Journal of Tea Science, 2025, 45(2): 318-332.