Welcome to Journal of Tea Science,Today is

Journal of Tea Science ›› 2017, Vol. 37 ›› Issue (5): 429-441.

    Next Articles

Determination of Green Tea Catechin Biomarkers and It′s Relative Application

SUN Lili1, ZENG Xiangquan2, Nilesh W Gaikwad3, WANG Huan4, XU Hairong1, YE Jianhui1,*   

  1. 1. Tea Research Institute, Zhejiang University, Hangzhou 310058, China;
    2. Shaoxing Entry-Exit Inspection and Quarantine Bureau, Shaoxing 312000, China;
    3. Department of Nutrition and Environmental Toxicology, University of California at Davis, Davis 95616, USA;
    4. Crop Research Institute, Zhejiang University, Hangzhou 310058, China
  • Received:2017-05-09 Revised:2017-05-30 Online:2017-10-25 Published:2019-08-23

Abstract: Green tea has been considered to have many health benefits, but there is still controversy about the clinical and epidemiological results. Development of green tea catechin biomarkers was to evaluate the physiological effects of green tea from a metabolic point of view, which will be helpful to interpret the functional mechanism of green tea in vivo and also avoid or reduce the influences of chemical compositions of samples intake or individual differences in human studies. Catechin compounds EGCG, EGC, EC, C, ECG and their derivatives are common green tea catechin biomarkers that have many determination methods including HPLC-EC, LC-MS and so on. This paper reviewed the types of green tea catechin biomarkers and their preparation and determination methods, discussed the results of biomarker-level based bioavailability studies, clinical trials and epidemiological studies, proposed suggestions for future research, such as further improvement and standardization of the preparation and determination methods of catechin biomarkers as well as development of new green tea biomarkers with higher stability in human body and sensitivity in reflecting their intake levels.

Key words: green tea catechin biomarker, HPLC-EC, catechin compounds, EGCG, metabolites, epidemiology, review

CLC Number: