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茶叶科学 ›› 2011, Vol. 31 ›› Issue (5): 405-410.doi: 10.13305/j.cnki.jts.2011.05.002

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茶多酚抗辐射制剂安全毒理学研究

王岳飞1, 梁善珠1,2, 张士康2, 陈红波1*, 朱跃进2, 黄爽如1, 杨贤强1   

  1. 1. 浙江大学茶学系,浙江 杭州 310029;
    2. 中华全国供销合作总社杭州茶叶研究院,浙江 杭州 310016
  • 收稿日期:2010-11-15 修回日期:2011-03-21 出版日期:2011-10-15 发布日期:2019-09-09
  • 通讯作者: chenhbo212@163.com
  • 作者简介:王岳飞(1968— ),男,浙江天台人,博士,主要从事茶叶生物化学与茶终端产品研究开发。
  • 基金资助:
    浙江省人事厅留学回国基金J20090040

Study on the Toxicology of an Anti-radiation Preparation of Tea-polyphenols

WANG Yue-fei1, LIANG Shan-zhu1,2, ZHANG Shi-kang2, CHEN Hong-bo1*, ZHU Yue-jin2, HUANG Shuang-ru1, YANG Xian-qiang1   

  1. 1. Department of Tea Science, Zhejiang University, Hangzhou 310029, China;
    2. Hangzhou Tea Research Institute, China COOP, Hangzhou 310016, China
  • Received:2010-11-15 Revised:2011-03-21 Online:2011-10-15 Published:2019-09-09

摘要: 为检测茶多酚抗辐射制剂的食用安全性,通过急性毒性试验、遗传毒性试验(Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验)、30d喂养试验进行毒理学研究。结果表明,雌雄两性大、小鼠经口MTD均大于20.0g/kg,Ames试验、小鼠骨髓微核试验、小鼠精子畸形试验3项遗传毒性试验结果均为阴性,显示无致突变性。30d喂养试验(5.00g/kg)未见动物出现中毒症状。试验结果显示,茶多酚抗辐射制剂急性毒性分级属无毒级、无遗传毒性,食用安全性高。

关键词: 茶多酚抗辐射制剂, 急性毒性, 最大耐受量, 遗传毒性, 安全性

Abstract: To evaluate the edible safety of anti-radiation preparations of tea polyphenol, the experiment included acute toxicity test, Ames test, micronucleus test, sperm shape abnormality test and thirty days feeding test were performed. Results showed that the oral maximum tolerance dose(MTD) was higher than 20.0 g/kg·bw both in female and male mice and rats. The results on toxicity of Ames test, micronucleus test, sperm shape abnormality test and mutagencity were negative. No toxicological symptom was appeared in tested animals from thirty days feeding test. It is concluded that the anti-radiation preparations of tea-polyphenol was classified as non-toxicology and genotoxicity, high edible safety.

Key words: anti-radiation preparations of tea-polyphenols, acute toxicity, maximum tolerated dose, genotoxicity, edible safety

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