EGCG对细胞的促氧化作用研究进展

陈怡君; 熊立瑰; 黄建安; 龚雨顺; 刘仲华

doi:10.13305/j.cnki.jts.2015.02.004

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茶叶科学 ›› 2015, Vol. 35 ›› Issue (2) : 130-136. DOI: 10.13305/j.cnki.jts.2015.02.004

EGCG对细胞的促氧化作用研究进展

陈怡君¹, 熊立瑰¹, 黄建安^1,2,3, 龚雨顺^1,*, 刘仲华^1,2,3,*

作者信息 +

Review on Pro-oxidative Properties of EGCG on Cell

CHEN Yijun¹, XIONG Ligui¹, HUANG Jian′an^1,2,3, GONG Yushun^1,*, LIU Zhonghua^1,2,3,*

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文章历史 +

摘要

EGCG是茶叶中主要的儿茶素类物质,具有多种生物活性。近年来,EGCG促氧化作用得到了广泛关注。本文对国内外细胞实验中EGCG的促氧化作用进行综述。EGCG在细胞培养基中发生自动氧化可以形成细胞外氧化应激环境,这种自动氧化受到培养基种类、EGCG浓度与处理时间、血清含量及pH值等因素影响。在细胞内,EGCG直接提高细胞内活性氧（Reactive Oxidative Species, ROS）和线粒体ROS,或者通过Fenton反应间接产生OH^-。EGCG可以影响细胞内转录因子、信号通路与表面生长因子受体的表达与传递,从而影响细胞的一系列生命活动。

Abstract

EGCG, which is the most abundant catechin in tea, has been demonstrated to possess a wide range of biochemical and pharmacological activities. Recent investigations have revealed that EGCG functions as a pro-oxidant. In this review, we discussed the pro-oxidative mechanism of EGCG in cell culture. Auto-oxidation of EGCG, influenced by the media types, dose- and time-dependent of EGCG addition, contents of serum and pH value etc., forms environmental oxidative stress in cell medium. Furthermore, EGCG produce intracellular ROS and mtROS, and trigger the Fenton reaction to create OH^- indirectly. In particular, pro-oxidation of EGCG regulate intracellular transcription factors, signalling pathways, and cell surface receptor to exert many biological actions in cell.

导出引用

陈怡君, 熊立瑰, 黄建安, 龚雨顺, 刘仲华. EGCG对细胞的促氧化作用研究进展[J]. 茶叶科学. 2015, 35(2): 130-136 https://doi.org/10.13305/j.cnki.jts.2015.02.004

CHEN Yijun, XIONG Ligui, HUANG Jian′an, GONG Yushun, LIU Zhonghua. Review on Pro-oxidative Properties of EGCG on Cell[J]. Journal of Tea Science. 2015, 35(2): 130-136 https://doi.org/10.13305/j.cnki.jts.2015.02.004

中图分类号： TS272 Q946.84+1

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