[1] 赵保路. 自由基、天然抗氧化剂与神经退行性疾病[J]. 生物物理学报, 2010, 26(4): 263-274. [2] 刘东华,毕明刚.中药提取成分抗阿尔茨海默病研究进展[J].国际药学研究杂志,2009,36(5):340-344. [3] 宛晓春. 茶叶生物化学: 第三版[M]. 北京: 中国农业出版社, 2003: 9, 30, 34, 39. [4] 朱永兴, Huang H.茶与健康[M]. 北京: 中国农业科学技术出版社, 2004: 5. [5] Zhao B L.The health effects of tea polyphenols and their antioxidant mechanism[J]. J Clin Biochem Nutr, 2006, 38: 59-68. [6] 高欣, 唐希灿. 神经退行性疾病的早期信号: 线粒体功能障碍[J]. 生命科学, 2006, 18(2): 138-144. [7] 王海燕, 张新卿. 茶的神经保护作用[J]. 中华老年医学杂志, 2006, 25(12): 942-945. [8] Assuncăo M, Santos-Marques M J, Carvalho F, et al. Chronic green tea consumption prevents age-related changes in rat hippocampal formation[J]. Neurobiol. Aging. doi:10.1016/j.neurobiolaging.2009.03.016. [9] Xu Y, Zhang J J, Xiong L, et al. Green tea polyphenols inhibit cognitive impairment induced by chronic cerebral hypoperfusion via modulating oxidative stress[J]. J Nutr Biochem, 2010, 21(8): 741-748. [10] Wei IH, Wu YC, Wen CY, et al. Green tea polyphenol (-)-epigallocatechin gallate attenuates the neuronal NADPH-d/nNOS expression in the nodose ganglion of acute hypoxic rats[J]. Brain Res, 2004, 999(1): 73-80. [11] Kim JS, Kim JM, O JJ, et al. Inhibition of inducible nitric oxide synthase expression and cell death by (-)-epigallocatechin-3-gallate, a green tea catechin, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease[J]. J Clin Neurosci, 2010, 17(98): 1165-1168. [12] 赵保路. 茶多酚保护脑神经防止帕金森病损伤作用及其分子机理[J]. 生物化学与生物物理进展, 2008, 35(7): 735-743. [13] 颜菡, 唐希灿. β-淀粉样蛋白的代谢与调控: 阿尔采末病的潜在治疗靶点[J]. 生命科学, 2007, 19(4): 409-416. [14] Jeon SY, Bae K, Seong YH, et al. Green tea catechins as a BACE1 (beta-secretase) inhibitor[J]. Bioorg Med Chem Lett, 2003, 13(22): 3905-3908. [15] Rezai-zadeh K, Shytle D, Sun N, et al.Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice[J]. J Neurosci, 2005, 25(38): 8807-8814. [16] Mandel SA, Amit T, Weinreb O, et al. Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases[J]. CNS Neurosci Therap, 2008, 14(4): 352-365. [17] Levites Y,Amit T,Mandel S, et al. Neuroprotection and neurorescue against Aβ toxicity and PKC-dependent release of non-amyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate[J]. FASEB J, 2003, 17(8): 952-954. [18] 田建英, 杨浩. nAChR 介导茶多酚EGCG的神经保护作用[J]. 中国药理学通报, 2007, 23(11): 1494-1496. [19] Bastianetto S, Yao ZX, Papadopoulos V, et al. Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity[J]. Eur J Neurosci, 2006, 23(1): 55-64. [20] Haque AM, Hashimoto M, Katakura M, et al. Green tea catechins prevent cognitive deficits caused by Aβ1-40 in rats[J]. J Nutr Biochem, 2008, 19(9): 619-626. [21] Kim CY, Lee C, Park GH, et al. Neuroprotective effect of epigallocatechin-3-gallate against β-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity[J]. Arch Pharmacal Res, 2009, 32(6): 869-881. [22] 徐铮奎. 天然镇静剂——茶氨酸产品开发现状与前景瞻望[J]. 中国制药信息, 2007, 23(3): 34-37. [23] Yamada T, Okubo T, Juneja LR, et al. Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission[J]. Nutr Neurosci, 2005, 8(4): 219-226. [24] Nathan PJ, Lu K, Gray M, et al. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent[J]. J Herb Pharmacother, 2006, 6(2): 21-30. [25] Rosso A, Mossey J, Lippa C.F. Caffeine: neuroprotective functions in cognition and Alzheimer’s disease[J]. Am J Alzheimer’s Dis Other Demen, 2008, 23(5): 417-422. [26] Lin SM, Wang SW, Ho SC, et al. Protective effect of green tea(-)-epigallocatechin-3-gallate against the monoamine oxidase B enzyme activity increase in adult rat brains[J]. Nutrition, doi:10.1016/j.nut.2009.11.022 [27] Bernareggi A, Dueńas Z, Reyes-Ruiz JM, et al. Properties of glutamate receptors of Alzheimer’s disease brain transplanted to frog oocytes[J]. Proc Natl Acad Sci, USA, 2007, 104(8): 2956-2960. [28] 严钰, 丁启龙. 中药单体及有效部位的神经保护作用机制研究进展[J]. 药学进展, 2007, 31(4): 154-159. [29] Di X, Yan j, Zhao Y, et al. L-theanine protects the app (swedish mutation) Transgenic sh-sy5y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway[J]. Neuroscience, 2010, 168(3): 778-786. [30] Yu JX, Jia YQ, Guo YS, et al. Epigallocatechin-3-gallate protects motor neurons and regulates glutamate level[J]. FEBS Lett, 2010, 584(13): 2921-2925. [31] Jang S, Jeong HS, Park JS, et al. Neuroprotective effects of (-)-epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition[J]. Brain Res, 2010, 1313: 25-33. [32] Adachi N, Tomonaga S, Tachibana T, et al. (-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain[J]. Eur J Pharmacol, 2006, 531/213: 171-175. [33] Vignes M, Maurice T, Lanté F, et al. Anxiolytic properties of green tea polyphenols (-)-epigallocatechin gallate (EGCG)[J]. Brain Res, 2006, 1110(1): 102-115. [34] 王潭, 席娜娜, 郑荣远. 咖啡碱作为中枢腺苷受体拮抗剂的应用[J]. 国际药学研究杂志, 2009, 36(4): 249-253. [35] Piccardi M, Congiu D, Squassina A, et al. Alzheimer′s disease: case2control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample[J]. Am J Med Genet B N europsychiatr Genet, 2007, 144(7): 895-899. [36] Okello EJ, Savelev SU, Perry E.K. In vitro anti-beta-secretase and dual anti-cholinesterase activities of Camellia sinensis L.(tea) relevant to treatment of dementia[J]. Phytother Res, 2004, 18(8): 624-627. [37] Li R, Peng N, Du F, et al. Epigallocatechin gallate protects dopaminergic neurons against 1-methyl-4-pheny1-1,2,3,6-tetrahydropyridine-induced neurotoxicity by inhibiting microglial cell activation[J]. J South Med Univ(南方医科大学学报), 2006, 26(4): 376-380. [38] Levites Y, Amit T, Youdim MB, et al. Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action[J]. J Biol. Chem, 2002, 277(34): 30574-30580. [39] Kalfon L, Youdim M B, Mandel S.A. Green tea polyphenol (-)-epigallocatechin-3-gallate promotes the rapid protein kinase C- and proteasome-mediated degradation of Bad: implications for neuroprotection[J]. J Neurochem, 2007, 100(4): 992-1002. [40] Li Q, Zhao HF, Zhang ZF, et al. Long-term administration of green tea catechins prevents age-related spatial learning and memory decline in C57BL/6 J mice by regulating hippocampal cyclic AMP-response element binding protein signaling cascade[J]. Neurosci, 2009, 159(4): 1208-1215 [41] Li Q, Zhao HF, Zhang ZF, et al. Long-term administration of green tea catechins prevents spatial learning and memory impairment in SAMP8 mice by decreasing Aβ1-42 oligomers and up-regulating synaptic plasticity related proteins in hippocampus[J]. Neurosci, 2009, 163(3): 741-749. [42] Connolly S, Kingsbury TJ.Caffeine modulates CREB-dependent gene expression in developing cortical neurons[J]. Biochem Biophys Res Commun, 2010, 397(2): 152-156. [43] 盛之玲, 曲梅花, 何海进, 等. HeLa、HEK293、SH-SY5Y细胞中的Tau 蛋白[J]. 生物化学与生物物理进展, 2008, 35(12): 1364-1370. [44] Rezai-Zadeh K, Arendash GW, Hou H, et al. Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice[J]. Brain Res, 2008, 1214: 177-187. [45] 方芳, 崔志清, 韩永晶. 茶儿茶素抗大鼠脑缺血再灌注损伤与对脑细胞内Ca2+的作用[J]. 中国药学杂志, 2003, 38(12): 917-919. [46] 冯亮, 徐辰, 郑浩, 等. 茶多酚对D2半乳糖诱导糖基化大鼠脑损害的干预作用[J]. 中国老年学杂志, 2008, 28(13): 1251-1254. [47] Akiyama H, Barg er S, Barnum S, et al. Inflammation and Alzheimer’s disease[J]. Neuro Biol Aging, 2000, 21(3): 383-421. [48] Brothers HM, Marchalant Y, Wenk GL.Caffeine attenuates lipopolysaccharide-induced neuroinflammation[J]. Neurosci Lett, 2010, 480(2): 97-100. [49] 陈国钱, 郑荣远, 王新施, 等. 咖啡碱对实验性自身免疫性脑脊髓炎大鼠的IFN-γ和TGF-β的影响[J]. 温州医学院学报, 2008, 38(6): 491-493. [50] Aktas O, Prozorovski T, Smorodchenko A, et al. Green tea epigallocatechin-3-gallate mediates T cellular NF-κB inhibition and exerts neuroprotection in Autoimmune Encephalomyelitis[J]. J Immunol, 2004, 173(9): 5794-5800. [51] Lee SY, Lee JW, Yoo HS, et al. Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms[J]. Mol Brain Res, 2005, 140(1/2): 45-54. [52] 蔡飞, 李彩蓉, 吴基良, 等. 茶黄素对大鼠脑缺血再灌注损伤后细胞凋亡及凋亡相关基因的影响[J]. 时珍国医国药, 2008, 19(6): 1396-1398. [53] 苏兴文, 皮荣标, 林穗珍, 等. 咖啡碱对谷氨酸诱导神经元凋亡的保护作用[J]. 中国药理学通报, 1999, 15(6): 509-512. [54] 王海燕, 张新卿. 茶对血管性认知功能损害的保护作用[J]. 中华预防医学杂志, 2007, 41(3): 222-224. [55] Sharangi AB.Medicinal and therapeutic potentialities of Tea (Camellia sinensis L.) - A review[J]. Food Res Int, 2009, 42(5/6): 529-535. [56] Lee H, Bae HB, Lee SR.Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils[J]. J Neurosci Res, 2004, 77(6): 892-900. [57] Arab L, Liu WQ, Elashoff D.Green and black tea consumption and risk of stroke: a Meta-analysis[J]. Stroke, 2009, 40(5): 1786-1792. [58] Arab L, Liebeskind DS.Tea, flavonoids and stroke in man and mouse[J]. Arch Biochem. Biophys, 2010, 501(1): 31-36. [59] Thielecke F, Boschmann M.The potential role of green tea catechins in the prevention of the metabolic syndrome - A review[J]. Phytochemistry, 2009, 70(1): 11-24. [60] 石亚亚, 贾尚智, 闵彩云. 茶氨酸保健功能研究进展[J]. 氨基酸和生物资源, 2010, 32(1): 52-56. [61] Haskell CF, Kennedy DO, Milne AL, et al. The effects of L-theanine, caffeine and their combination on cognition and mood[J]. Biol Psychol, 2008, 77(2): 113-122. [62] Einöther SJL, Martens VEG, Rycroft JA, et al. L-Theanine and caffeine improve task switching but not intersensory attention or subjective alertness[J]. Appetite, 2010, 54(2): 406-409. [63] Park KW, Oh JH, Yoo HS, et al. (-)-Epigallocatechin-3-O-gallate (EGCG) reverses caffeine-induced anxiogenic-like effects[J]. Neurosci. Lett., 2010, 481(2): 131-134. [64] 马强. 体力运动益于脑健康的神经生物学基础[J]. 解放军预防医学杂志, 2008, 26(4): 305-308. [65] Murase T, Haramizu S, Ota N, et al. Tea catechin ingestion combined with habitual exercise suppresses the aging-associated decline in physical performance in senescence-accelerated mice[J].Am J Physiol, 2008, 295(1): R281-R289. [66] Huo C, Wan SB, Lam WH, et al. The challenge of developing green tea polyphenols as therapeutic agents[J]. Immunopharm, 2008, 16(5): 248-252. |