茶叶的神经保护作用研究进展

doi:10.13305/j.cnki.jts.2011.02.001

摘要/Abstract

摘要： 现代医学研究表明,茶叶中的有效成分儿茶素、L-茶氨酸、咖啡碱等可通过互作,多途径、多靶点发挥神经保护作用。在神经保护中,茶叶可通过抗氧化清除自由基,调节神经递质如谷氨酸、γ-氨基丁酸、腺苷、乙酰胆碱等及其相关受体、阻止tau蛋白磷酸化、防止胞内Ca²⁺超载、调节蛋白激酶PKC等信号途径、调节炎症因子、提升神经营养因子水平、消除血管性危险因素、防止细胞凋亡等途径发挥功效。本文就近年来茶叶的神经保护作用相关机制的研究结果作一简要综述。

关键词: 茶叶, 活性成分, 抗氧化, 神经保护

Abstract: Tea is a natural healthy beverage and recent medicinal researches have been proven that teas have the neuroprotection function. In the neuroprotective effects of tea, catechins, L-theanine and caffeine work together to modulate the nervous system especially central nervous system in a multi-targets way through multiple pathways. Tea showed the free radical Scavenging function via the antioxidative roles. Besides, it showed the function of modulation the neurotransmitters as glutamic acid, γ-aminobutyric acid and acetylcholine etc. and their related receptors, prevention of tau protein phosphorylation and intracellular calcium overloads, regulation of protein kinase C signal transduction pathway, modulation of inflammatory factors, elevation of the neurotrophic factors’ level, elimination of vascular risk factors and attenuation of neuron apoptosis. Recent progress on the neuroprotective effects of tea was reviewed in this paper.

Key words: tea, active component, antioxidation, neuroprotection

中图分类号:

TS272
R742

李大祥, 鲜殊, 杨卫, 宛晓春. 茶叶的神经保护作用研究进展[J]. 茶叶科学, 2011, 31(2): 79-86. doi: 10.13305/j.cnki.jts.2011.02.001.

LI Da-xiang, XIAN Shu, YANG Wei, WAN Xiao-chun. Progress on the Neuroprotective Effects of Tea[J]. Journal of Tea Science, 2011, 31(2): 79-86. doi: 10.13305/j.cnki.jts.2011.02.001.

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