Abstract: The adjusting effects of Oolong tea polysaccharide (OTPS) on serum lipid in hyperlipoidemia mice and its mechanism were investigated. The hyperlipidmia mice model was established by feeding high lipid diet, and different groups were taken OTPS by intragastric administration for 6 weeks. In present investigation, body weight, thymus weight, spleen weight, liver weight, blood lipid levels, malondialdehyde (MDA) and liver superoxide dismutase (SOD) activities of serum and liver were measured, as well the histopathological changes in tissues of liver were observed. The results showed that the contents of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), serum and liver MDA, liver index were lower in comparison with the high hyperlipoidemia model group, while thymus index, spleen index, serum and liver SOD activities were somewhat higher, and the liver lesions were restored in some degree. It is indicated that OTPS showed a positive effect on adjusting the serum lipid, improving immunity of body and antioxidation.

Key words: Oolong tea polysaccharide, serum lipid, antioxidation