Welcome to Journal of Tea Science,Today is

Journal of Tea Science ›› 2014, Vol. 34 ›› Issue (4): 401-407.doi: 10.13305/j.cnki.jts.2014.04.013

Previous Articles     Next Articles

Research on the Antihyperlipdemic Activity of Theaflavins, Catechins and Saponius Mixture Preparations

ZHANG Cong1,2,3, TAN Rong2,3,*, KONG Junhao2,3, GE Qingfeng1, YANG Xiufang2,3, WANG Zhijun1   

  1. 1. College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China;
    2. Hangzhou Tea Research Institute, CHINA COOP, Hangzhou 310016, China;
    3. Zhejiang key laboratory of transboundary applied technology for tea resources, Hangzhou 310016, China
  • Received:2013-12-11 Revised:2014-02-10 Online:2014-08-15 Published:2019-09-03

Abstract: The antihyperlipdemic activity in vitro of theaflavins(TFs), catechins(Cs) and saponius(SPs) were assessed in lipid clearance rate in the model of HepG2 steatosis by using the admini stration with 1 mmol·L-1 oleic acid(OA) in 24 h. Based on the cell viability test(MTT value), lipid clearance was used to evaluate the effect of TFs, Cs and SPs on HepG2 steatosis. The response surface methodology based on a Box-Behnken experimental design was used to optimize the density of the three extractions for combined lipid-lowering in vitro. Results indicated that TFs, Cs and SPs showed a significant inhibitory effect on TG accumulation in HepG2 cells. The ability of lipid-lowering was significant promoted when the three extractions acted on HepG2 at the same time. TFs, Cs and SPs could showed the prevention and curing effect of hyperlipidemia.

Key words: theaflavins, catechins, saponius, in vitro, antihyperlipdemic

CLC Number: