Effects of Catechins on Acute Hyperuricemia in Mice

JIN Hongna; SONG Yewei; CUI Weibo; XIE Hong

doi:10.13305/j.cnki.jts.2016.04.002

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Journal of Tea Science ›› 2016, Vol. 36 ›› Issue (4) : 347-353. DOI: 10.13305/j.cnki.jts.2016.04.002

Effects of Catechins on Acute Hyperuricemia in Mice

JIN Hongna¹, SONG Yewei¹, CUI Weibo², XIE Hong^1,*

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Abstract

The mouse model of acute hyperuricemia was established by using 300 mg·kg^-1 oxonic acid potassium salt to evaluate the influence of catechins on serum uric acid. The xanthine oxidase (XOD) activity in serum and liver and the inhibitory effect of catechins on XOD in vitro was further studied. Results showed that with dosage of 600 mg·kg^-1, EC, ECG and EGC reduced the serum uric acid level in vivo significantly by 23% (P<0.001), 35% (P<0.001) and 37% (P<0.001), respectively compared with the model group. ECG could reduce XOD activity in serum and liver approximately by 31% (P<0.01) and 32% (P<0.05). In vitro, ECG and EGCG could inhibit XOD activity. Therefore EC, ECG and EGC could reduce the level of uric acid of hyperuricemia mice. The mechanism of uric acid lowering effect of ECG might be associated with its inhibitory effect on XOD.

Key words

catechins / hyperuricemia / xanthine oxidase

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JIN Hongna, SONG Yewei, CUI Weibo, XIE Hong. Effects of Catechins on Acute Hyperuricemia in Mice[J]. Journal of Tea Science. 2016, 36(4): 347-353 https://doi.org/10.13305/j.cnki.jts.2016.04.002

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