Inhibitory Effects of Tea and Tea Catechins on Breast Cancer

QIAO Ruying; LI Ming; ZHENG Xinqiang; LU Jianliang; YE Jianhui; WANG Kairong; LIANG Yuerong

doi:10.13305/j.cnki.jts.2016.06.002

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Journal of Tea Science ›› 2016, Vol. 36 ›› Issue (6) : 557-566. DOI: 10.13305/j.cnki.jts.2016.06.002

Inhibitory Effects of Tea and Tea Catechins on Breast Cancer

QIAO Ruying¹, LI Ming², ZHENG Xinqiang¹, LU Jianliang¹, YE Jianhui¹, WANG Kairong³, LIANG Yuerong^1,*

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Abstract

Tea with high catechin contents has various health benefits. There are more than ten catechins in tea, among which epigallocatechin gallate (EGCG) is the most abundant. The inhibitory effects of tea and its major catechin (EGCG) on breast cancer were reviewed in the present paper, which included their abilities of suppressing carcinogen-induced ROS elevation and DNA damages, decreasing the responsiveness of cells to tumor necrosis factors, blocking the binding of estrogen to estrogen receptor, inhibiting DNA methylation, protecting mitochondria from oxidative damages and inhibiting tumor angiogenesis. The anti-proliferation and anti-metastasis of cancer cells and their synergistic effects with anticancer drugs were also mentioned. The inconsistent results in previous studies and directions for future research were finally discussed.

Key words

anticancer / antioxidant / anti-proliferation / catechins / estrogen receptor / metastasis / tea

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QIAO Ruying, LI Ming, ZHENG Xinqiang, LU Jianliang, YE Jianhui, WANG Kairong, LIANG Yuerong. Inhibitory Effects of Tea and Tea Catechins on Breast Cancer[J]. Journal of Tea Science. 2016, 36(6): 557-566 https://doi.org/10.13305/j.cnki.jts.2016.06.002

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