绿茶儿茶素类生物标记物的检测及应用

Abstract

Abstract: Green tea has been considered to have many health benefits, but there is still controversy about the clinical and epidemiological results. Development of green tea catechin biomarkers was to evaluate the physiological effects of green tea from a metabolic point of view, which will be helpful to interpret the functional mechanism of green tea in vivo and also avoid or reduce the influences of chemical compositions of samples intake or individual differences in human studies. Catechin compounds EGCG, EGC, EC, C, ECG and their derivatives are common green tea catechin biomarkers that have many determination methods including HPLC-EC, LC-MS and so on. This paper reviewed the types of green tea catechin biomarkers and their preparation and determination methods, discussed the results of biomarker-level based bioavailability studies, clinical trials and epidemiological studies, proposed suggestions for future research, such as further improvement and standardization of the preparation and determination methods of catechin biomarkers as well as development of new green tea biomarkers with higher stability in human body and sensitivity in reflecting their intake levels.

Key words: green tea catechin biomarker, HPLC-EC, catechin compounds, EGCG, metabolites, epidemiology, review

CLC Number:

SUN Lili, ZENG Xiangquan, Nilesh W Gaikwad, WANG Huan, XU Hairong, YE Jianhui. Determination of Green Tea Catechin Biomarkers and It′s Relative Application[J]. Journal of Tea Science, 2017, 37(5): 429-441.

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Determination of Green Tea Catechin Biomarkers and It′s Relative Application

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