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Journal of Tea Science ›› 2012, Vol. 32 ›› Issue (6): 471-479.doi: 10.13305/j.cnki.jts.2012.06.003

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Application of Caco-2 Cell Model in the Research of Tea Bioactive Components

XIE Yan-lan1, GUO Hao-wei1, ZHENG Xian-mu1, XU Hai-rong1*, Wilfried Andlauer2, Agnieszka Kosińska2   

  1. 1. Department of Tea Science, Zhejiang University, Hangzhou 310058, China;
    2. Life Technologies Institute, University of Applied Sciences Valais (HES-SO), Sion, CH-1950, Switzerland;
  • Received:2012-07-06 Revised:2012-08-14 Online:2012-12-15 Published:2019-09-05

Abstract: Caco-2 cell monolayer possesses the similar morphological and functional properties to the human intestinal epithelial cells, is one of the important in vitro cell models to study nutrients or drugs absorption, transport and metabolism. In recent years the Caco-2 cell model also widely used in the research of tea bioactive components. The absorption and transport mechanisms of catechins, theanine, gallic acid and caffeine, the metabolism of catechins and the pharmacodynamic mechanism of tea bioactive components in Caco-2 cells were reviewed. What’s more, the rapid assessment of tea bioactive components’ absorption features using Caco-2 cell model in order to promote the development of tea-care products and preparations were prospected.

Key words: Caco-2 cell model, tea, bioactive components, absorption and transport, metabolism, pharmacodynamic mechanism, review

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