Caco-2细胞模型在茶叶生物活性成分研究中的应用

doi:10.13305/j.cnki.jts.2012.06.003

Abstract

Abstract: Caco-2 cell monolayer possesses the similar morphological and functional properties to the human intestinal epithelial cells, is one of the important in vitro cell models to study nutrients or drugs absorption, transport and metabolism. In recent years the Caco-2 cell model also widely used in the research of tea bioactive components. The absorption and transport mechanisms of catechins, theanine, gallic acid and caffeine, the metabolism of catechins and the pharmacodynamic mechanism of tea bioactive components in Caco-2 cells were reviewed. What’s more, the rapid assessment of tea bioactive components’ absorption features using Caco-2 cell model in order to promote the development of tea-care products and preparations were prospected.

Key words: Caco-2 cell model, tea, bioactive components, absorption and transport, metabolism, pharmacodynamic mechanism, review

CLC Number:

TS272
Q946.8

XIE Yan-lan, GUO Hao-wei, ZHENG Xian-mu, XU Hai-rong, Wilfried Andlauer, Agnieszka Kosińska. Application of Caco-2 Cell Model in the Research of Tea Bioactive Components[J]. Journal of Tea Science, 2012, 32(6): 471-479.

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Application of Caco-2 Cell Model in the Research of Tea Bioactive Components

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