茶的抗病毒作用研究进展

doi:10.13305/j.cnki.jts.2021.02.001

Abstract

Abstract: Tea (Camellia sinensis) is known as a global health beverage, and global tea consumption increases due to its biological activities. In the last 30 years, antiviral activities of tea and its components, especially tea polyphenols, with different modes of action were demonstrated on diverse families of viruses, such as influenza virus, coronavirus, hepatitis virus, and human immunodeficiency virus, etc. This review summarized the current knowledge on the antiviral activities of tea and its components. Most of these studies demonstrated antiviral properties of tea and its components by in vitro biochemical or cell experiments with little rodent and clinical studies. Therefore, it is still unclear whether the antiviral effects of daily tea consumption are available. More large-scale randomized intervention and epidemiological/clinical studies are needed to confirm clinical efficacy of tea and its components.

Key words: tea, functional components, virus, antiviral activities

CLC Number:

S571.1
R373

XIONG Ligui, LIU Sihui, HUANG Jian'an, LIU Zhonghua. The Antiviral Properties of Tea[J]. Journal of Tea Science, 2021, 41(2): 143-158.

References

[1] Green R H.Inhibition of multiplication of influenza virus by extracts of tea[J]. Proceedings of the Society for Experimental Biology and Medicine, 1949, 71(1): 84-85.
[2] Eisfeld A J, Neumann G, Kawaoka Y.At the centre: Influenza A virus ribonucleoproteins[J]. Nature Reviews Microbiology, 2014, 13(1): 28-41.
[3] Paules C I, Sullivan S G, Subbarao K, et al.Chasing seasonal influenza: the need for a universal influenza vaccine[J]. New England Journal of Medicine, 2018, 378(1): 7-9.
[4] Chen G H, Lin Y L, Hsu W L, et al.Significant elevation of antiviral activity of strictinin from Pu'er tea after thermal degradation to ellagic acid and gallic acid[J]. Journal of Food & Drug Analysis, 2015, 23(1): 116-123.
[5] Xu J, Xu Z, Zheng W.A review of the antiviral role of green tea catechins[J]. Molecules, 2017, 22(8): 1337. doi: 10.3390/molecules22081337.
[6] 黄深惠, 汤有志, 周雪梦, 等. 茶多酚体内外抗流感病毒作用研究[J]. 茶叶科学, 2010, 30(4): 302-308.
Huang S H, Tang Y Z, Zhou M X, et al.Study on anti-influenza virus effect of tea polyphenols in vitro and in vivo[J]. Journal of Tea Science, 2010, 30(4): 302-308.
[7] 彭慧琴, 蔡卫民, 项哨. 茶多酚体外抗流感病毒A3的作用[J]. 茶叶科学, 2003, 23(1): 79-81.
Peng H Q, Cai W M, Xiang S.In vitro anti-influenza virus effect of tea polyphenols[J]. Journal of Tea Science, 2003, 23(1): 79-81.
[8] Zu M, Yang F, Zhou W, et al.In vitro anti-influenza virus and anti-inflammatory activities of theaflavin derivatives[J]. Antiviral Research, 2012, 94(3): 217-224.
[9] 肖潇, 杨占秋, 石丽桥, 等. 表没食子儿茶素没食子酸酯抗流感病毒作用的研究[J]. 中国中药杂志, 2008, 33(22): 2678-2682.
Xiao X, Yang Z Q, Shi L Q, et al.Antiviral effect of epigallocatechin gallate (EGCG) on influenza A virus[J]. China Journal of Chinese Materia Medica, 2008, 33(22): 2678-2682.
[10] 谭文界, 石丽桥, 祝汪洋, 等. (-)表没食子儿茶素-3-O-没食子酸酯(EGCG)的抗流感病毒实验[J]. 中国医院药学杂志, 2009, 29(5): 376-378.
Tan W J, Shi L Q, Zhu W Y, et al.Study on the effect of anti-influenza virus of EGCG[J]. Chinese Journal of Hospital Pharmacy, 2009, 29(5): 376-378.
[11] 谢慧珺, 刘妮, 丁伟, 等. 茶多酚主要成分EGCG体外抗流感病毒FM1株作用[J]. 广州中医药大学学报, 2012, 29(2): 172-175, 224.
Xie H J, Liu N, Ding W, et al.Antiviral effect of tea catechin EGCG on influenza virus FM1 strain in vitro[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2012, 29(2): 172-175, 224.
[12] Yang Z F, Bai L P, Huang W B, et al.Comparison of in vitro antiviral activity of tea polyphenols against influenza A and B viruses and structure-activity relationship analysis[J]. Fitoterapia, 2014, 93: 47-53.
[13] Noda M, Toda M, Endo W, et al.The anti-influenza virus activities of catechins[J]. Jpn J Bacteriol, 1994, 49: 117.
[14] Song J M, Lee K H, Seong B L.Antiviral effect of catechins in green tea on influenza virus[J]. Antiviral Research, 2005, 68(2): 66-74.
[15] Nakayama M, Suzuki K, Toda M, et al.Inhibition of the infectivity of influenza virus by tea polyphenols[J]. Antiviral Research, 1993, 21(4): 289-299.
[16] 李湘潋, 刘叔文, 杨洁. 茶黄素衍生物抗甲型流感病毒的作用研究[J]. 中草药, 2013, 44(17): 2437-2441.
Li X L, Liu S W, Yang J.Effect of theaflavin derivatives on influenza A virus[J]. Chinese Traditional and Herbal Drugs, 2013, 44(17): 2437-2441.
[17] Imanishi N, Tuji Y, Katada Y, et al.Additional inhibitory effect of tea extract on the growth of influenza A and B viruses in MDCK cells[J]. Microbiology & Immunology, 2002, 46(7): 491-494.
[18] Furuta T, Hirooka Y, Abe A, et al.Concise synthesis of dideoxy-epigallocatechin gallate (DO-EGCG) and evaluation of its anti-influenza virus activity[J]. Cheminform, 2007, 38(40): 3095-3098.
[19] Ling J X, Wei F, Li N, et al.Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea[J]. Acta Pharmacologica Sinica, 2012, 33(12): 1533-1541.
[20] Oxford J S, Lambkin R, Guralnik M, et al.Preclinical in vitro activity of QR-435 against influenza A virus as a virucide and in paper masks for prevention of viral transmission[J]. American Journal of Therapeutics, 2007, 14(5): 455-461.
[21] Sriwilaijaroen N, Fukumoto S, Kumagai K, et al.Antiviral effects of Psidium guajava Linn. (guava) tea on the growth of clinical isolated H1N1 viruses: Its role in viral hemagglutination and neuraminidase inhibition[J]. Antiviral Research, 2012, 94(2): 139-146.
[22] Oxford J S, Lambkin R, Guralnik M, et al.In vivo prophylactic activity of QR-435 against H3N2 influenza virus infection[J]. American Journal of Therapeutics, 2007, 14(5): 462-468.
[23] Lee H J, Lee Y N, Youn H N, et al.Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens[J]. Poultry Science, 2011, 91(1): 66-73.
[24] Leung P C.Antibacterial and antiviral effects of tea-from influenza to SARS[J]. Protective Effects of Tea on Human Health, 2006(16): 158-171.
[25] Park M, Yamada H, Matsushita K, et al.Green tea consumption is inversely associated with the incidence of influenza infection among schoolchildren in a tea plantation area of Japan[J]. Journal of Nutrition, 2011, 141(10): 1862-1870.
[26] Rowe C, Nantz M, Bukowski J, et al.Specific formulation of Camellia sinensis prevents cold and flu symptoms and enhances gamma, delta t cell function: A randomized, double-blind, placebo-controlled study[J]. Journal of the American College of Nutrition, 2007, 26(5): 445-452.
[27] Matsumoto K, Yamada H, Takuma N, et al.Effects of green tea catechins and theanine on preventing influenza infection among healthcare workers: a randomized controlled trial[J]. BMC Complementary and Alternative Medicine, 2011, 11: 15. doi: 10.1186/1472-6882-11-15.
[28] Iwata M, Toda M, Nakayama M, et al.Prophylactic effect of black tea extract as gargle against influenza[J]. Kansenshōgaku Zasshi the Journal of the Japanese Association for Infectious Diseases, 1997, 71(6): 487-494.
[29] Noda T, Ojima T, Hayasaka S, et al.Gargling for oral hygiene and the development of fever in childhood: a population study in Japan[J]. Journal of Epidemiology, 2012, 22(1): 45-49.
[30] Yamada H, Takuma N, Daimon T, et al.Gargling with tea catechin extracts for the prevention of influenza infection in elderly nursing home residents: a prospective clinical study[J]. Journal of Alternative and Complementary Medicine, 2006, 12(7): 669-672.
[31] Ide K, Yamada H, Kawasaki Y.Effect of gargling with tea and ingredients of tea on the prevention of influenza infection: A meta-analysis[J]. BMC Public Health, 2016, 16: 396. doi: 10.1186/s12889-016-3083-0.
[32] Ide K, Yamada H, Matsushita K, et al.Effects of green tea gargling on the prevention of influenza infection in high school students: a randomized controlled study[J]. Plos One, 2014, 9: e96373. doi: 10.1371/journal.pone.0096373.
[33] Steinmann, Buer, Pietschmann, et al. Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea[J]. British Journal of Pharmacology, 2013, 168: 1059-1073.
[34] Zhu N, Zhang D, Wang W, et al.A novel coronavirus from patients with pneumonia in China, 2019[J]. New England Journal of Medicine, 2020, 382: 727-733.
[35] Cui J, Li F, Shi Z L.Origin and evolution of pathogenic coronaviruses[J]. Nature Reviews Microbiology, 2019, 17: 181-192.
[36] Jiang Y, Xu J, Zhou C, et al.Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome[J]. American Journal of Respiratory and Critical Care Medicine, 2005, 171(8): 850-857.
[37] Peihua N, Guangyu Z, Yao D.A novel human mAb (MERS-GD27) provides prophylactic and postexposure efficacy in MERS-CoV susceptible mice[J]. Science China, 2018, 61(10): 148-150.
[38] Wu C R, Zheng M Z, Yang Y, et al.Furin, a potential therapeutic target for COVID-19[J]. iScience, 2020, 23(10): 101642. doi: 10.1016/j.isci.2020.101642.
[39] Chen C N, Lin C P C, Huang K K, et al. Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3'-digallate (TF3)[J]. Evidence-Based Complementary and Alternative Medicine, 2005, 2(2): 209-215.
[40] Kamath A B, Wang L, Das H, et al.Antigens in tea-beverage prime human Vγ2Vδ2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses[J]. PNAS, 2003, 100(10): 6009-6014.
[41] Matsumoto M, Mukai T, Furukawa S, et al.Inhibitory effects of epigallocatechin gallate on the propagation of bovine coronavirus in Madin-Darby bovine kidney cells[J]. Animal Science Journal, 2005, 76: 507-512.
[42] Clark K J, Grant P G, Sarr A B, et al.An in vitro study of theaflavins extracted from black tea to neutralize bovine rotavirus and bovine coronavirus infections[J]. Veterinary Microbiology, 1998, 63(2/4): 147-157.
[43] Liang W L, He L, Ning P B, et al.(+)-Catechin inhibition of transmissible gastroenteritis coronavirus in swine testicular cells is involved its antioxidation[J]. Research in Veterinary Science, 2015, 103: 28-33.
[44] Deeks S G, Overbaugh J, Phillips A, et al.HIV infection[J]. Nature Reviews Disease Primers, 2015, 1: 15035. doi: 10.1038/nldp.2015.35.
[45] Fauci A S, Redfield R R, Sigounas G, et al.Ending the HIV epidemic: a plan for the United States[J]. The Journal of the American Medical Association, 2019, 321: 844-845.
[46] Huang N, Yang L M, Li X L et al. Anti-HIV activities of extracts from Pu-erh tea[J]. Chinese Journal of Natural Medicines, 2012, 10(5): 347-352.
[47] Pasetto S, Pardi V, Murata R M.Anti-HIV-1 activity of flavonoid myricetin on HIV-1 infection in a dual-chamber in vitro model[J]. Plos One, 2014, 9(12): e115323. doi: 10.1371/journal.pone.0115323.
[48] Su Y L, Rhim J Y, Park W B.Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro[J]. Archives of Pharmacal Research, 2005, 28(11): 1293-1301.
[49] Nakane H, Ono K.Differential inhibition of HIV-reverse transcriptase and various DNA and RNA polymerases by some catechin derivatives[J]. Nucleic Acids Symp Ser, 1989, 21(21): 115-116.
[50] Chang C, Hsu F, Lin J.Inhibitory effects of polyphenolic catechins from Chinese green tea on HIV reverse transcriptase activity[J]. Journal of Biomedical Science, 1994, 1(3): 163-166.
[51] Li S, Hattori T, Kodama E N.Epigallocatechin gallate inhibits the HIV reverse transcription step[J]. Antiviral Chemistry and Chemotherapy, 2011, 21(6): 239-243.
[52] Fassina G, Buffa A, Benelli R, et al.Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent[J]. Aids, 2002, 16(6): 939-941.
[53] Yamaguchi K, Honda M, Ikigai H, et al.Inhibitory effects of (-)-epigallocatechin gallate on the life cycle of human immunodeficiency virus type 1 (HIV-1)[J]. Antiviral Research, 2002, 53(1): 19-34.
[54] Freed E O.HIV-1 assembly, release and maturation[J]. Nature Reviews Microbiology, 2015, 13(8): 484-496.
[55] Hamza A, Zhan C G.How can (-)-epigallocatechin gallate from green tea prevent HIV-1 infection? Mechanistic insights from computational modeling and the implication for rational design of anti-HIV-1 entry inhibitors[J]. Journal of Physical Chemistry B, 2006, 110(6): 2910-2917.
[56] Kawai K, Tsuno N H, Kitayama J, et al.Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding[J]. Journal of Allergy & Clinical Immunology, 2003, 112(5): 951-957.
[57] Williamson M, Mccormick T, Nance C, et al.Epigallocatechin gallate, the main polyphenol in green tea, binds to the T-cell receptor, CD4: potential for HIV-1 therapy[J]. Journal of Allergy & Clinical Immunology, 2006, 118(6): 1369-1374.
[58] Nance C L, Siwak E B, Shearer W T.Preclinical development of the green tea catechin, epigallocatechin gallate, as an HIV-1 therapy[J]. Journal of Allergy & Clinical Immunology, 2009, 123(2): 459-465.
[59] Jiang F, Chen W, Yi K, et al.The evaluation of catechins that contain a galloyl moiety as potential HIV-1 integrase inhibitors[J]. Clinical Immunology, 2010, 137(3): 347-356.
[60] Liu S, Lu H, Zhao Q, et al.Theaflavin derivatives in black tea and catechin derivatives in green tea inhibit HIV-1 entry by targeting gp41[J]. Biochimica et Biophysica Acta General Subjects, 2005, 1723(1/3): 270-281.
[61] Yang J, Li L, Tan S, et al.A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: potential applications for preventing HIV-1 infection[J]. Fitoterapia, 2012, 83(2): 348-355.
[62] Liu S W, Wu S G, Jiang S B.HIV entry inhibitors targeting gp41: from polypeptides to small-molecule compounds[J]. Current Pharmaceutical Design, 2007, 13(2): 143-162.
[63] Ehrnhoefer D E, Bieschke J, Boeddrich A, et al.EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers[J]. Nature Structural & Molecular Biology, 2008, 15(6): 558-566.
[64] Hauber I, Hohenberg H, Holstermann B, et al.The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection[J]. PNAS, 2009, 106(22): 9033-9038.
[65] Hartjen P, Frerk S, Hauber I, et al.Assessment of the range of the HIV-1 infectivity enhancing effect of individual human semen specimen and the range of inhibition by EGCG[J]. Aids Research & Therapy, 2012, 9: 2. doi: 10.1186/1742-6405-9-2.
[66] Popovych N, Brender J R, Soong R, et al.Site specific interaction of the polyphenol EGCG with the SEVI amyloid precursor peptide PAP(248-286)[J]. Journal of Physical Chemistry B, 2012, 116(11): 3650-3658.
[67] Yang J, Li L, Jin H, et al.Vaginal gel formulation based on theaflavin derivatives as a microbicide to prevent HIV sexual transmission[J]. AIDS Research and Human Retroviruses, 2012, 28(11): 1498-1508.
[68] Manns M P, Buti M, Gane E, et al.Hepatitis C virus infection[J]. Nature reviews Disease primers, 2017, 3: 17006. doi: 10.1038/nrdp.2017.6.
[69] Yuen M F, Chen D S, Dusheiko G M, et al.Hepatitis B virus infection[J]. Nature Reviews Disease Primers, 2018, 338(18): 1312-1313.
[70] Razavi-Shearer D, Gamkrelidze I, Nguyen M H, et al.Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study[J]. Lancet Gastroenterol Hepatol, 2018, 3(6): 383-403.
[71] Xu J, Wang J, Deng F, et al.Green tea extract and its major component epigallocatechin gallate inhibits hepatitis B virus in vitro[J]. Antiviral Research, 2008, 78(3): 242-249.
[72] Pei S, Zhang Y, Xu H, et al.Inhibition of the replication of hepatitis B virus in vitro by Pu-erh tea extracts[J]. Journal of Agricultural & Food Chemistry, 2011, 59(18): 9927-9934.
[73] 廖银武. 白茶提取物抗乙型肝炎病毒的研究[D]. 福州: 福建农林大学, 2010.
Liao Y W.The study of anti-HBV effect of white tea extract [D]. Fuzhou: Fujian Agriculture and Forestry University, 2010.
[74] Ye P, Zhang S, Zhao L, et al.Tea polyphenols exerts anti-hepatitis B virus effects in a stably HBV-transfected cell line[J]. Journal of Huazhong University of Science and Technology (Medical Sciences), 2009, 29(2): 169-172.
[75] Xu J, Gu W, Li C, et al.Epigallocatechin gallate inhibits hepatitis B virus via farnesoid X receptor alpha[J]. Journal of Natural Medicines, 2016, 70(3): 584-591.
[76] Pang J Y, Zhao K J, Wang J B, et al.Green tea polyphenol, epigallocatechin-3-gallate, possesses the antiviral activity necessary to fight against the hepatitis B virus replication in vitro[J]. Journal of Zhejiang University-Science B, 2014, 15(6): 533-539.
[77] Karamese M, Aydogdu S, Karamese S A, et al.Preventive effects of a major component of green tea, epigallocathechin-3-gallate, on hepatitis-B virus DNA replication[J]. Asian Pacifc Journal of Cancer Prevention, 2015, 16(10): 4199-4202.
[78] Cheng Z K, Sun G, Guo W, et al.Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines[J]. Virologica Sinica, 2015, 30: 261-268.
[79] Zheng Z, Li J, Sun J, et al.Inhibition of HBV replication by theophylline[J]. Antiviral Research, 2011, 89(2): 149-155.
[80] He W, Lx LX, Liao QJ, et al.Epigallocatechin gallate inhibits HBV DNA synthesis in a viral replication-inducible cell line[J]. World Journal of Gastroenterology, 2011, 17(11): 1507-1514.
[81] Yan H, Zhong G C, Xu G W, et al.Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus[J]. Elife Sciences, 2012, 1: e00049. doi: 10.7554/eLife.00049.
[82] Yan H, Peng B, He W, et al.Molecular determinants of hepatitis B and D virus entry restriction in mouse sodium taurocholate cotransporting polypeptide[J]. Journal of Virology, 2013, 87(14): 7977-7991.
[83] Huang H C, Tao M H, Hung T M, et al.(-)-Epigallocatechin-3-gallate inhibits entry of hepatitis B virus into hepatocytes[J]. Antiviral Research, 2014, 111: 100-111.
[84] Zhong L, Hu J, Shu W, et al.Epigallocatechin-3-gallate opposes HBV-induced incomplete autophagy by enhancing lysosomal acidification, which is unfavorable for HBV replication[J]. Cell Death & Disease, 2015, 6(5): e1770. doi: 10.1038/cddis.2015.136.
[85] Lai Y H, Sun C P, Huang H C, et al.Epigallocatechin gallate inhibits hepatitis B virus infection in human liver chimeric mice[J]. BMC Complementary and Alternative Medicine, 2018, 18: 248. doi: 10.1186/s12906-018-2316-4.
[86] Wang Z Y, Li Y Q, Guo Z W, et al.ERK1/2-HNF4α axis is involved in epigallocatechin-3-gallate inhibition of HBV replication[J]. Acta Pharmacologica Sinica, 2020, 41(2): 278-285.
[87] Thrift A P, El-Serag H B, Kanwal F. Global epidemiology and burden of HCV infection and HCV-related disease[J]. Nat Rev Gastroenterol Hepatol, 2016, 14(2): 122-132.
[88] Calland N, Albecka A, Belouzard S, et al.(-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry[J]. Hepatology, 2012, 55(3): 720-729.
[89] Ciesek S, Hahn T V, Che C C, et al.The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry[J]. Hepatology, 2011, 54(6): 1947-1955.
[90] Chen C, Qiu H, Gong J, et al.(-)-Epigallocatechin-3-gallate inhibits the replication cycle of hepatitis C virus[J]. Archives of Virology, 2012, 157(7): 1301-1312.
[91] Zuo G, Li Z, Chen L, et al.Activity of compounds from Chinese herbal medicine Rhodiola kirilowii (Regel) maxim against HCV NS3 serine protease[J]. Antiviral Research, 2007, 76(1): 86-92.
[92] Fukazawa H, Suzuki T, Wakita T, et al.A cell-based, microplate colorimetric screen identifies 7,8-benzoflavone and green tea gallate catechins as inhibitors of the hepatitis C virus[J]. Biological & Pharmaceutical Bulletin, 2012, 35(8): 1320-1327.
[93] Mekky R Y, El-Ekiaby N, Sobky S A E, et al. Epigallocatechin gallate (EGCG) and miR-548m reduce HCV entry through repression of CD81 receptor in HCV cell models[J]. Archives of Virology, 2019, 164(6): 1587-1595.
[94] Witteveldt J, Evans M J, Bitzegeio J, et al.CD81 is dispensable for hepatitis C virus cell-to-cell transmission in hepatoma cells[J]. The Journal of General Virology, 2009, 90(1): 48-58.
[95] Calland N, Sahuc M E, Belouzard S, et al.Polyphenols inhibit hepatitis C virus entry by a new mechanism of action[J]. Journal of Virology, 2015, 89: 10053-10063.
[96] Lin Y T, Wu Y H, Chin-Kai T, et al.Green tea phenolic epicatechins inhibit hepatitis C virus replication via cycloxygenase-2 and attenuate virus-induced inflammation[J]. Plos One, 2013, 8(1): e54466. doi: 10.1371/journal.pone.0054466.
[97] Chowdhury P, Sahuc Me, Rouillé Y, et al.Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture[J]. Plos One, 2018, 13(11): e0198226. doi: 10.1371/journal.pone.0198226.
[98] Crosbie E J, Einstein D H, Franceschi S, et al.Human papillomavirus and cervical cancer[J]. The Lancet, 2013, 382: 889-899.
[99] Zou C, Liu H, Feugang J M, et al.Green tea compound in chemoprevention of cervical cancer[J]. International Journal of Gynecologic Cancer, 2010, 20(4): 617-624.
[100] Qiao Y, Cao J, Xie L, et al.Cell growth inhibition and gene expression regulation by (-)-epigallocatechin-3-gallate in human cervical cancer cells[J]. Archives of Pharmacal Research, 2009, 32(9): 1309-1315.
[101] Yokoyama M, Noguchi M, Nakao Y, et al.The tea polyphenol, (-)-epigallocatechin gallate effects on growth, apoptosis, and telomerase activity in cervical cell lines[J]. Gynecologic Oncology, 2004, 92(1): 197-204.
[102] He L, Zhang E, Shi J, et al.(-)-Epigallocatechin-3-gallate inhibits human papillomavirus (HPV)-16 oncoprotein-induced angiogenesis in non-small cell lung cancer cells by targeting HIF-1α[J]. Cancer Chemotherapy & Pharmacology, 2013, 71(3): 713-725.
[103] Singh M, Tyagi S, Bhui K, et al.Regulation of cell growth through cell cycle arrest and apoptosis in HPV 16 positive human cervical cancer cells by tea polyphenols[J]. Investigational New Drugs, 2010, 28(3): 216-224.
[104] Singh M, Singh R, Bhui K, et al.Tea polyphenols induce apoptosis through mitochondrial pathway and by inhibiting nuclear factor-κB and Akt activation in human cervical cancer cells[J]. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 2011, 19: 245-257.
[105] Ahn W S, Yoo J, Huh S W, et al.Protective effects of green tea extracts (polyphenon E and EGCG) on human cervical lesions[J]. European Journal of Cancer Prevention, 2003, 12(5): 383-390.
[106] Tatti S, Stockfleth E, Beutner K R, et al.Polyphenon E: a new treatment for external anogenital warts[J]. British Journal of Pharmacology, 2010, 162(1): 176-184.
[107] Stockfleth E, Meyer T.The use of sinecatechins (polyphenon E) ointment for treatment of external genital warts[J]. Expert Opinion on Biological Therapy, 2012, 12(6): 783-793.
[108] Garcia F A, Cornelison T, Nuño T, et al.Results of a phase II randomized, double-blind, placebo-controlled trial of Polyphenon E in women with persistent high-risk HPV infection and low-grade cervical intraepithelial neoplasia[J]. Gynecologic Oncology, 2013, 132: 377-382.
[109] Date A A, Destache C J.Natural polyphenols: potential in the prevention of sexually transmitted viral infections[J]. Drug Discovery Today, 2016, 21(2): 333-341.
[110] Johnson D C, Baines J D.Herpesviruses remodel host membranes for virus egress[J]. Nature Reviews Microbiology, 2011, 9(5): 382-394.
[111] Molloy S.Back to the HSV drawing board[J]. Nature Reviews Microbiology, 2012, 10: 82. doi: 10.1038/nrmicro2744.
[112] Savi L A, Barardi C R, Simões C M.Evaluation of antiherpetic activity and genotoxic effects of tea catechin derivatives[J]. Journal of Agricultural & Food Chemistry, 2006, 54(7): 2552-2557.
[113] Isaacs C E, Wen G Y, Xu W, et al.Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus[J]. Antimicrobial Agents & Chemotherapy, 2008, 52(3): 962-970.
[114] Colpitts C C, Schang L M.A small molecule inhibits virion attachment to heparan sulfate- or sialic acid-containing glycans[J]. Journal of Virology, 2014, 88(14): 7806-7817.
[115] Daikoku T, Horiba K, Miyata K, et al.Polyphenols including catechin from green tea with in vitro antiviral activity exhibited anti-herpes simplex virus activity but not anti-influenza virus activity in mice[J]. Journal of Traditional Medicines, 2011, 28(2): 63-72.
[116] Isaacs C E, Xu W, Merz G, et al.Digallate dimers of (-)-epigallocatechin gallate inactivate herpes simplex virus[J]. Antimicrobial Agents & Chemotherapy, 2011, 55(12): 5646-5653.
[117] Chang L K, Wei T T, Chiu Y F, et al.Inhibition of Epstein-Barr virus lytic cycle by (-)-epigallocatechin gallate[J]. Biochemical & Biophysical Research Communications, 2003, 301(4): 1062-1068.
[118] Yan Z, Hai W, Zhao X R, et al.Epigallocatechin-3-gallate interferes with EBV-encoding AP-1 signal transduction pathway[J]. Zhonghua Zhong Liu Za Zhi, 2004, 26(7): 393-397.
[119] Liu S, Li H, Chen L, et al.(-)-Epigallocatechin-3-gallate inhibition of Epstein-Barr virus spontaneous lytic infection involves ERK1/2 and PI3-K/Akt signaling in EBV-positive cells[J]. Carcinogenesis, 2012, 34(3): 627-637.
[120] Chen Y L, Tsai H L, Peng C W.EGCG debilitates the persistence of EBV latency by reducing the DNA binding potency of nuclear antigen 1[J]. Biochemical and Biophysical Research Communications, 2012, 417(3): 1092-1099.
[121] 张国营, 何丽娜. 红茶,青茶,黑茶抗人轮状病毒的实验研究[J]. 中国病毒学, 1993, 8(2): 151-153.
Zhang G Y, He L N.An experimental study on antiviral activities of black tea, blue tea and dark tea against rotavirus[J]. Virologica Sinica, 1993, 8(2): 151-153.
[122] Ho H Y, Cheng M L, Weng S F, et al.Antiviral effect of epigallocatechin gallate on enterovirus 71[J]. Journal of Agricultural and Food Chemistry, 2009, 57(14): 6140-6147.
[123] Weber J M, Ruzindana-Umunyana A, Imbeault L, et al.Inhibition of adenovirus infection and adenain by green tea catechins[J]. Antiviral Research, 2003, 58(2): 167-173.
[124] Weber C, Sliva K, Von Rhein C, et al.The green tea catechin, epigallocatechin gallate inhibits chikungunya virus infection[J]. Antiviral Research, 2015, 113: 1-3.
[125] Carneiro B M, Batista M N, Braga A C S, et al. The green tea molecule EGCG inhibits Zika virus entry[J]. Virology, 2016, 496: 215-218.
[126] Bansal S, Choudhary S, Sharma M, et al.Tea: a native source of antimicrobial agents[J]. Food Research International, 2013, 53(2): 568-584.
[127] Evers D L, Chao C F, Wang X, et al.Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action[J]. Antiviral Research, 2005, 68(3): 124-134.
[128] NAIR M P N, Kandaswami C, Mahajan S, et al. The flavonoid, quercetin, differentially regulates Th-1 (IFNγ) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells[J]. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2002, 1593(1): 29-36.
[129] Chow H H, Cai Y, Hakim I A, et al.Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals[J]. Clinical Cancer Research, 2003, 9(9): 3312-3319.
[130] Mori S, Miyake S, Kobe T, et al.Enhanced anti-influenza A virus activity of (-)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: effect of alkyl chain length[J]. Bioorganic & Medicinal Chemistry Letters, 2008, 18(14): 4249-4252.
[131] De Oliveira A, Adams S D, Lee L H, et al.Inhibition of herpes simplex virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate[J]. Food & Chemical Toxicology, 2013, 52: 207-215.
[132] Kaihatsu K, Mori S, Matsumura H, et al.Broad and potent anti-influenza virus spectrum of epigallocatechin-3-O-gallate-monopalmitate[J]. Journal of Molecular & Genetic Medicine, 2009, 3(2): 195-197.
[1] Zhong Y, Ma C M, Shahidi F.Antioxidant and antiviral activities of lipophilic epigallocatechin gallate (EGCG) derivatives[J]. Journal of Functional Foods, 2012, 4(1): 87-93.

The Antiviral Properties of Tea

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