Theanine Depressed the Food Intake and Gastric Emptying in Female Mice via Lateral Hypothalamic AMPA and NMDA Receptor

YU Xi-chong; YANG Wei; WU Bo-la

doi:10.13305/j.cnki.jts.2013.05.008

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Journal of Tea Science ›› 2013, Vol. 33 ›› Issue (5) : 429-435. DOI: 10.13305/j.cnki.jts.2013.05.008

Theanine Depressed the Food Intake and Gastric Emptying in Female Mice via Lateral Hypothalamic AMPA and NMDA Receptor

YU Xi-chong^1,2, YANG Wei³, WU Bo-la²

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Abstract

In the present study, the food intake and gastric emptying of female mice were evaluated after theanine microinjection in cerebral ventrile, lateral hypothalamus, arcurate nuleius and ventromedial hypothalamic nucleus. Results showed that theanine 3~30βmg/kg intraperitoneal injection decreased food intake and gastric emptying; theanine 3~100βng microinjection into cerebral ventrile induced “V” style effects on gastric, theanine 3~30βng decreased gastric emptying dose-dependently while theanine 50 and 100βng recovered gastric emptying. Theanine microinjection in lateral hypothalamus displayed similar effects on gastic emptying as theanine i.c.v while microinjection in arcurate nucleus and ventromedial hypothalamic nucleus did not alert gastric emptying. Theanine decreased food intake and gastric emptying induced by NMDA and AMPA microinjection in lateral hypothalamus. It

Key words

AMPA / food intake / gastric emptying / lateral hypothalamus / NMDA / theanine

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YU Xi-chong, YANG Wei, WU Bo-la. Theanine Depressed the Food Intake and Gastric Emptying in Female Mice via Lateral Hypothalamic AMPA and NMDA Receptor[J]. Journal of Tea Science. 2013, 33(5): 429-435 https://doi.org/10.13305/j.cnki.jts.2013.05.008

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