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Journal of Tea Science ›› 2013, Vol. 33 ›› Issue (5): 429-435.doi: 10.13305/j.cnki.jts.2013.05.008

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Theanine Depressed the Food Intake and Gastric Emptying in Female Mice via Lateral Hypothalamic AMPA and NMDA Receptor

YU Xi-chong1,2, YANG Wei3, WU Bo-la2   

  1. 1. Department of pharmacology of traditional Chinese medicine, Zhejiang Chinese medical university, Hangzhou 310053, China;
    2. Department of pharmacology, Wenzhou medical college, Wenzhou 325035, China;
    3. Department of pharmacy, Wenzhou medical college, Wenzhou 325035, China
  • Received:2013-02-20 Revised:2013-06-22 Online:2013-10-30 Published:2019-09-04

Abstract: In the present study, the food intake and gastric emptying of female mice were evaluated after theanine microinjection in cerebral ventrile, lateral hypothalamus, arcurate nuleius and ventromedial hypothalamic nucleus. Results showed that theanine 3~30βmg/kg intraperitoneal injection decreased food intake and gastric emptying; theanine 3~100βng microinjection into cerebral ventrile induced “V” style effects on gastric, theanine 3~30βng decreased gastric emptying dose-dependently while theanine 50 and 100βng recovered gastric emptying. Theanine microinjection in lateral hypothalamus displayed similar effects on gastic emptying as theanine i.c.v while microinjection in arcurate nucleus and ventromedial hypothalamic nucleus did not alert gastric emptying. Theanine decreased food intake and gastric emptying induced by NMDA and AMPA microinjection in lateral hypothalamus. It

Key words: theanine, lateral hypothalamus, food intake, gastric emptying, NMDA, AMPA

CLC Number: