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Journal of Tea Science ›› 2010, Vol. 30 ›› Issue (6): 414-422.doi: 10.13305/j.cnki.jts.2010.06.002

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Molecular Targets for Cancer Chemoprevention by (-)-Epigallocatechin Gallate of Green Tea

GU Cheng-bo1,2,5, YUAN Xiao-han3,4, FU Yu-jie1,2, ZU Yuan-gang1,2,*, ZHAO En-ze1,2, LI Wang1,2, WANG Qiu-xue1,2   

  1. 1. Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China;
    2. Engineering Research Center of Forest Bio-preparation, Ministry of Education, Northeast Forestry University, Harbin 150040, China;
    3. College of Forestry, Northeast Forestry University, Harbin 150040, China;
    4. Life Science and Biotechnique Research Center, Northeast Agricultural University, Harbin 150030, China;
    5. Zhejiang Hisun Pharmaceutical Co. Ltd, Taizhou 318000, China
  • Received:2010-01-06 Revised:2010-03-11 Published:2019-09-11

Abstract: (-)-Epigallocatechin gallate (EGCG) is the most active and major polyphenolic compound in green tea. The molecular mechanisms and targets on the action of EGCG have been extensively investigated. This paper reviewed some of the reported mechanisms and possible targets for the action of EGCG, and strategies for cancer chemoprevention by EGCG in clinical trials were discussed. It provides a new inspiration for cancer chemoprevention.

Key words: EGCG, cancer chemoprevention, molecular mechanisms, molecular targets

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