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Journal of Tea Science ›› 2016, Vol. 36 ›› Issue (2): 119-130.doi: 10.13305/j.cnki.jts.2016.02.002

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Research Advance in Synthesis and Pharmacological Effects of EGCG Derivatives

LIU Min, RAO Guowu, HUA Yunfen*   

  1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China
  • Received:2015-09-29 Online:2016-04-15 Published:2019-08-23

Abstract: (-)-Epigallocatechin-3-gallate (EGCG), one of the important catechins in tea, has efficient bioactivity of cell experiment in vitro and animal models in vivo. However, it was not being fully utilized because of the disadvantages of poor liposolubility and stability, as well as low bioavailability, which was resulted from its ‘polyhydroxy’ chemical structure. Excitingly, the molecular modification would be used to improve the physicochemical character of EGCG. This review will summarize the methods on molecular modification of EGCG and investigation of biological activities, which hopes to provide worthful references to the further study of EGCG.

Key words: EGCG, molecular modification, derivatives, review, bioactivity

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