Research Advance in Synthesis and Pharmacological Effects of EGCG Derivatives

LIU Min; RAO Guowu; HUA Yunfen

doi:10.13305/j.cnki.jts.2016.02.002

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Journal of Tea Science ›› 2016, Vol. 36 ›› Issue (2) : 119-130. DOI: 10.13305/j.cnki.jts.2016.02.002

Research Advance in Synthesis and Pharmacological Effects of EGCG Derivatives

LIU Min, RAO Guowu, HUA Yunfen^*

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Abstract

(-)-Epigallocatechin-3-gallate (EGCG), one of the important catechins in tea, has efficient bioactivity of cell experiment in vitro and animal models in vivo. However, it was not being fully utilized because of the disadvantages of poor liposolubility and stability, as well as low bioavailability, which was resulted from its ‘polyhydroxy’ chemical structure. Excitingly, the molecular modification would be used to improve the physicochemical character of EGCG. This review will summarize the methods on molecular modification of EGCG and investigation of biological activities, which hopes to provide worthful references to the further study of EGCG.

Key words

bioactivity / derivatives / EGCG / molecular modification / review

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LIU Min, RAO Guowu, HUA Yunfen. Research Advance in Synthesis and Pharmacological Effects of EGCG Derivatives[J]. Journal of Tea Science. 2016, 36(2): 119-130 https://doi.org/10.13305/j.cnki.jts.2016.02.002

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